Felis ISSN 2398-2950

Tolfenamic acid

Synonym(s): Tolfedine

Contributor(s): Kyle Braund

Introduction

Name

  • Tolfenamic acid.

Class of drug

  • Non-steroidal anti-inflammatory drug (NSAID).

Uses

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Indications

  • Used to control mild to moderate pain and inflammation in osteoarthritic conditions.
  • Used in febrile conditions.
  • Used as an adjunct to antibiotics in the management of upper respiratory tract conditions.
  • Ocular inflammation.

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs

Corticosteroids, other NSAIDs, methoxyflurane
  • Do not use with tolfenamic acid.

Anti-hypertensives, eg beta-blockers

  • Tolfenamic acid may antagonize the hypotensive effects.

Diuretics

  • Concominant use may increase the risk of nephrotoxicty.

Protein-bound drugs, eg coumarins, anesthetics

  • Displaced by NSAIDs, thereby potentiating their effects.

Fluoroquinolones

  • In man - increased risk of convulsions if NSAIDs concurrently administered with fluoroquinolones.

with diagnostic tests

T3 and T4
  • May cause false low values.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Ricketts A Pet al(1998)Evaluation of selective inhibition of canine cyclooxygenase 1 and 2 by carprofen and other nonsteroidal anti-inflammatory drugs.Am J Vet Res59(11), 1441-1446.

Other sources of information

  • Based onSmall Animal Formulary.Tennant Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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