Felis ISSN 2398-2950

Tobramycin

Contributor(s): Lauren Trepanier

Introduction

Name

  • Tobramycin.

Class of drug

  • Aminoglycoside antibiotic.

Uses

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Indications

  • An aminoglycoside antibiotic which is used to treat Gram-negative infections.
  • It is less active against most Gram-negative organisms than gentamicin   Gentamicin  but appears to be more active againstPseudomonas aeruginosa.
  • Aminoglycosides are ineffective at sites of low oxygen tension eg abscesses.
  • All obligate anaerobes are resistant.

Administration

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Pharmocokinetics

Precautions

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Interactions

with other drugs

Nephrotoxic, ototoxic or neurotoxic agents (eg amphotericin B, cisplatin, furosemide, NSAIDs)
  • Avoid concurrent use.
  • Increase monitoring and adjust dosages when these drugs must be used together.

Beta-lactam antibiotics (eg penicillins, cephalosporins)

  • Aminoglycosides may be inactivated when mixedin vitro.

Heparin

  • Aminoglycosides may be inactivated when mixedin vitro. This may also present a problemin vivoin patients who have substantially diminished renal function.

Non-depolarizing muscle relaxants (eg gallamine, metocurine, pancuronium, suxamethonium, tubocurarine)

  • Effect may be enhanced by aminoglycosides.

Penicillins or cephalosporins (Strep. fecalis), ticarcillin (Pseudomonas aeruginosa)

  • Synergism may occur.

Adverse Reactions

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Further Reading

Publications

Other sources of information

  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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