Felis ISSN 2398-2950

Tetracycline

Contributor(s): Lauren Trepanier

Introduction

Name

  • Tetracycline.

Class of drug

  • Tetracycline antibiotic.

Description

Storage requirements

  • Avoid excessive exposure to heat or light - oxidized drug is nephrotoxic.

Uses

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Indications

  • A bacteriostatic antibiotic which inhibits the growth of many Gram-positive and Gram-negative bacteria, mycoplasma   Mycoplasma and Ureaplasma  , Ehrlichiae, Rickettsia spp, Borrelia (Lyme disease), Leptospiuria, Brucella and other microbes.
  • Tetracycline differs from oxytetracycline   Oxytetracycline  in its lipid solubility (oxytetracycline low solubility, tetracycline intermediate solubility) although this is unlikely to be of clinical relevance.
  • Ophthalmic tetracycline is the preferred agent for the treatment of chlamydia   Chlamydia disease  , mycoplasma or rickettsial eye infections.
  • Tetracycline is also used to cause pleurodesis.

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs

Penicillins
  • The bactericidal action of the penicillins may be inhibited by bacteriostatic antibiotics.

Drugs inhibiting absorption of orally administered tetracyclines

Digoxin

  • The bioavailability of digoxin   Digoxin  may be increased by tetracyclines for months after their discontinuation. This may lead to digoxin toxicity.

Anticoagulants

  • Plasma prothrombin activity may be decreased by tetracyclines and therefore patients on anticoagulant therapy may need a dose adjustment.

Methoxyflurane

  • Tetracyclines may increase the nephrotoxic effects of methoxyflurane   Methoxyflurane  .

Theophyllines

  • The gastrointestinal (GI) effects of tetracyclines may be increased.

with diagnostic tests

  • Plasma prothrombin activity may be decreased.

Adverse Reactions

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Further Reading

Publications

Other sources of information

  • Tennant B (1999)Small Animal Formulary.3rd edn. Cheltenham: British Small Animal Veterinary Association. ISBN 0 905214 52 8.

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