Felis ISSN 2398-2950

Terfenadine

Contributor(s): Rosanna Marsella

Introduction

Name

  • Terfenadine.

Class of drug

  • Antihistamine.

Uses

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Indications

Allergies
  • May be used in the management of allergic skin disease.
  • Not very effective for pruritus.

Administration

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Pharmocokinetics

Precautions

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Interactions

with other drugs

Imidazole antifungals, eg ketoconazole
  • Reduce the metabolism of terfenadine   Ketoconazole  .

  • Macrolides, eg erythromycin
  • Reduce the metabolism of terfenadine   Erythromycin  .

  • Arrhythmogenic drugs
  • Should be avoided to reduce the risk of arrhythmias developing.

  • Drugs likely to produce electrolyte imbalances
  • Particularly hypokalemia, eg diuretics, should be avoided to reduce the risk of arrhythmias developing.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Gras J & Llenas J (1999)Effects of H1 antihistamines on animal models of QTc prolongation.Druf saf 199921Suppl 1; 39-44, discussion 81-7.
  • Usui T, Sugiyama A, Ishida Y, Satoh Y, Sasaki Y & Hashimoto K (1998)Simultaneous assessment of the hemodynamic, cardiomechanical and electrophysiological effects of terfenadine on the in vivo canine model.Heart Vessels13(2), 49-57.
  • Otto D W & Greentree W F (1994)Terfenadine toxicosis in dogs.JAVMA205(7), 1004-1006.
  • Scott D W, Miller W H Jr, Cayette S M & Decker G A (1994)Failure of terfenadine as an antipruritic agent in atopic dogs - results of a double-blinded, placebo-controlled study.Can Vet J35(5), 286-288.

Other sources of information

  • Based onSmall Animal Formulary.Tennant Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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