ISSN 2398-2950      

Terfenadine

ffelis
Contributor(s):

Rosanna Marsella


Introduction

Name

  • Terfenadine.

Class of drug

  • Antihistamine.

Uses

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Indications

Allergies
  • May be used in the management of allergic skin disease.
  • Not very effective for pruritus.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

Imidazole antifungals, eg ketoconazole
  • Reduce the metabolism of terfenadine   Ketoconazole  .

  • Macrolides, eg erythromycin
  • Reduce the metabolism of terfenadine   Erythromycin  .

  • Arrhythmogenic drugs
  • Should be avoided to reduce the risk of arrhythmias developing.

  • Drugs likely to produce electrolyte imbalances
  • Particularly hypokalemia, eg diuretics, should be avoided to reduce the risk of arrhythmias developing.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Gras J & Llenas J (1999) Effects of H1 antihistamines on animal models of QTc prolongation. Druf saf 1999 21 Suppl 1; 39-44, discussion 81-7.
  • Usui T, Sugiyama A, Ishida Y, Satoh Y, Sasaki Y & Hashimoto K (1998) Simultaneous assessment of the hemodynamic, cardiomechanical and electrophysiological effects of terfenadine on the in vivo canine model.Heart Vessels 13 (2), 49-57.
  • Otto D W & Greentree W F (1994) Terfenadine toxicosis in dogs. JAVMA 205 (7), 1004-1006.
  • Scott D W, Miller W H Jr, Cayette S M & Decker G A (1994) Failure of terfenadine as an antipruritic agent in atopic dogs - results of a double-blinded, placebo-controlled study. Can Vet J 35 (5), 286-288.

Other sources of information

  • Based on Small Animal Formulary. Tennant B (1999) 3rd edn. BSAVA, UK.
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