Felis ISSN 2398-2950

Telmisartan

Synonym(s): Semintra®

Contributor(s): Rebecca Geddes, Linda Horspool

Introduction

Name

  • Telmisartan 4 mg/mL; Semintra®.

Class of drug

  • Benzenoids.
  • Biphenyls and derivatives.
  • Angiotensin II antagonists.

Description

Chemical name

  • 2-(4-{[4-methyl-6-(1-methyl-1H-1,3-benzodiazol-2-yl)-2-propyl-1H-1,3-benzodiazol-1-yl]methyl}phenyl)benzoic acid.

Molecular formula

  • C33H30N4O2

Molecular weight

  • 515

Physical properties

  • Clear, colorless to yellowish viscous solution.

Storage requirements

  • Shelf life as packaged for sale: 3 years.
  • Shelf life after first opening: 6 months.

Uses

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Indications

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs

  • Angiotensin converting enzyme inhibitors, eg benazepril   Benazepril  due to effects of ACE inhibitors   ACE inhibitors: overview   on renin-angiotensin-aldosterone system (RAAS).
  • Non-steroidal anti-inflammatory drugs (NSAIDs)   Analgesia: NSAID  , eg meloxicam   Meloxicam   due to effects of NSAID on renal vasculature (prostaglandins).
  • No clinical evidence of hypotension during concomitant therapy with amlodipine   Amlodipine  .  

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references fromVetMed ResourceandPubMed.
  • Ebner T, Schänzle G, Weber W, Sent U, Elliott J. (2013)In vitro glucuronidation of the angiotensin II receptor antagonist telmisartan in the cat: a comparison with other species.J Vet Pharmacol Ther36, 154-160PubMed.
  • Rüster C, Wolf G (2006)Renin-angiotensin-aldosterone system and progression of renal disease.J Am Soc Nephrol17, 2985-2991PubMedFull article

Other sources of information

Organisation(s)


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