ISSN 2398-2950      

Telmisartan

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Synonym(s): Semintra®


Introduction

Name

  • Telmisartan 4 mg/mL; Semintra®.
  • Telmisartan 10 mg/mL; Semintra®.

Class of drug

  • Benzenoids.
  • Biphenyls and derivatives.
  • Angiotensin II antagonists.

Description

Chemical name

  • 4’-[(1,4’-dimethyl2’propyl[2,6’-bi-1H-benzimidazol]-1’-yl)methyl]-[1,1’-biphenyl]-2-carboxylic acid.

Molecular formula

  • C33H30N4O2

Molecular weight

  • 514.63

Physical properties

  • Clear, colorless to yellowish viscous solution.

Storage requirements

  • Shelf life as packaged for sale: 3 years.
  • Shelf life after first opening: 6 months.
  • Store at or below 25°C (77°F).

Uses

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Indications

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

  • Angiotensin converting enzyme inhibitors, eg benazepril Benazepril due to effects of ACE inhibitors ACE inhibitors: overview on renin-angiotensin-aldosterone system (RAAS).
  • Non-steroidal anti-inflammatory drugs (NSAIDs) Analgesia: NSAID, eg meloxicam  Meloxicam due to effects of NSAID on renal vasculature (prostaglandins).
  • No clinical evidence of hypotension during concomitant therapy with amlodipine Amlodipine.  

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from VetMedResource and PubMed.
  • Coleman A E, Brown S A, Traas A M, Bryson L, Zimmering T, Zimmerman A (2019) Safety and efficacy of orally administered telmisartan for the treatment of systemic hypertension in cats: Results of a double-blind, placebo-controlled, randomized clinical trial. J Vet Intern Med 33 (2), 478-488 PubMed.
  • Glaus T M, Elliott J, Herberich E, Zimmering T, Albrecht B (2019) Efficacy of long-term oral telmisartan treatment in cats with hypertension: Results of a prospective European clinical trial. J Vet Intern Med 33 (2), 413-422 PubMed.
  • Sent U, Gössl R, Elliott J, Syme HM, Zimmering T (2015) Comparison of Efficacy of Long-term Oral Treatment with Telmisartan and Benazepril in Cats with Chronic Kidney Disease. J Vet Intern Med 29 (6), 1479-1487 PubMed.
  • Ebner T, Schänzle G, Weber W, Sent U, Elliott J (2013) In vitro glucuronidation of the angiotensin II receptor antagonist telmisartan in the cat: a comparison with other species. J Vet Pharmacol Ther 36, 154-160 PubMed.
  • Rüster C, Wolf G (2006) Renin-angiotensin-aldosterone system and progression of renal disease. J Am Soc Nephrol 17, 2985-2991 PubMed Full article

Other sources of information

  • Brown S A (2013) Renal Dysfunction in Small Animals. In: Merck Veterinary Manual.
  • Elliott J, Watson A D J (2010 Revised 2013) Overview of the IRIS staging system for CKD. www.iris-kidney.com
  • European Medicines Agency. Semintra. Summary of Product Characteristics. www.ema.europa.eu
  • European Medicines Agency. European Public Assessment Report. Semintra. Scientific Discussion. www.ema.europa.eu
  • Grauer G (2013) Measurement and interpretation of proteinuria and albuminuria. International Renal Interest Society www.iris-kidney.com
  • International Renal Interest Society (2013) IRIS treatment recommendations for CKD. www.iris-kidney.com

Organisation(s)

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