Felis ISSN 2398-2950

Telmisartan

Synonym(s): Semintra®

Contributor(s): Rebecca Geddes, Linda Horspool, Julien Bazelle

Introduction

Name

  • Telmisartan 4 mg/mL; Semintra®.
  • Telmisartan 10 mg/mL; Semintra®.

Class of drug

  • Benzenoids.
  • Biphenyls and derivatives.
  • Angiotensin II antagonists.

Description

Chemical name

  • 4’-[(1,4’-dimethyl2’propyl[2,6’-bi-1H-benzimidazol]-1’-yl)methyl]-[1,1’-biphenyl]-2-carboxylic acid.

Molecular formula

  • C33H30N4O2

Molecular weight

  • 514.63

Physical properties

  • Clear, colorless to yellowish viscous solution.

Storage requirements

  • Shelf life as packaged for sale: 3 years.
  • Shelf life after first opening: 6 months.
  • Store at or below 25°C (77°F).

Uses

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Indications

Administration

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Precautions

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Interactions

with other drugs

  • Angiotensin converting enzyme inhibitors, eg benazepril Benazepril due to effects of ACE inhibitors ACE inhibitors: overview on renin-angiotensin-aldosterone system (RAAS).
  • Non-steroidal anti-inflammatory drugs (NSAIDs) Analgesia: NSAID, eg meloxicam  Meloxicam due to effects of NSAID on renal vasculature (prostaglandins).
  • No clinical evidence of hypotension during concomitant therapy with amlodipine Amlodipine.  

Adverse Reactions

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Further Reading

Publications

Refereed papers

  • Recent references from VetMed Resource and PubMed.
  • Coleman A E, Brown S A, Traas A M, Bryson L, Zimmering T, Zimmerman A (2019) Safety and efficacy of orally administered telmisartan for the treatment of systemic hypertension in cats: Results of a double-blind, placebo-controlled, randomized clinical trial. J Vet Intern Med 33(2), 478-488 PubMed.
  • Glaus T M, Elliott J, Herberich E, Zimmering T, Albrecht B (2019) Efficacy of long-term oral telmisartan treatment in cats with hypertension: Results of a prospective European clinical trial. J Vet Intern Med 33(2), 413-422 PubMed.
  • Sent U, Gössl R, Elliott J, Syme HM, Zimmering T (2015) Comparison of Efficacy of Long-term Oral Treatment with Telmisartan and Benazepril in Cats with Chronic Kidney Disease. J Vet Intern Med 29(6), 1479-1487 PubMed.
  • Ebner T, Schänzle G, Weber W, Sent U, Elliott J (2013) In vitro glucuronidation of the angiotensin II receptor antagonist telmisartan in the cat: a comparison with other species. J Vet Pharmacol Ther 36, 154-160 PubMed.
  • Rüster C, Wolf G (2006) Renin-angiotensin-aldosterone system and progression of renal disease. J Am Soc Nephrol 17, 2985-2991 PubMed Full article

Other sources of information

Organisation(s)


ADDED