ISSN 2398-2950      

Suxamethonium

ffelis
Contributor(s):

John Dodam

Vetstream Ltd

Synonym(s): Succinycholine


Introduction

Name

  • Suxamethonium.

Class of drug

Uses

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Indications

  • Few, if any, indications for use in the dog.
  • Used to facilitate endotracheal intubation in cats and primates.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

Do not use if organophosphorus flea treatment used in last month as this can prolong action of suxamethonium from days to weeks.

Drugs enhancing action of suxamethonium

Neostigmine and pyridostigmine

  • Should not be administered with suxamethonium as they inhibit pseudocholinesterases, thereby enhancing effect of suxamethonium.

Diazepam

  • May reduce the duration of action of suxamethonium.

Digoxin

  • Suxamethonium may cause a sudden outflux of potassium from muscle cells, which may initiate arrhythmias. This also happens in animals with denervation-type diseases.
    Anticholinesterase drugs aggravate blockade and prolong action.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • BSAVA Small Animal Formulary. Ramsey I (2017) 9th edn. Cheltenham: BSAVA.
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