Felis ISSN 2398-2950

Sulfasalazine

Synonym(s): Sulphasalazine

Contributor(s): Lauren Trepanier

Introduction

Name

  • Sulfasalazine.

Class of drug

  • Sulfonamide/Salicylate.

Description

Molecular formula

  • 5-aminosalicylic acid (5-ASA) and sulfapyridine connected by an azo bond.

Uses

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Indications

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs

Digoxin
  • Absorption may be decreased by sulfasalazine   Digoxin  .
    Folic acid
  • Absorption may be decreased by sulfasalazine   Folic acid  .
    Drugs whose action may be enhanced
  • Sulfonamides may displace highly protein bound acidic drugs such as:
  • Glipizide   Glipizide  and other oral hypoglycemics.
  • Methotrexate   Methotrexate  .
  • Phenylbutazone   Phenylbutazone  .
  • Phenytoin   Phenytoin  .
  • Salicylates.
  • Thiazide diuretics.
  • Warfarin   Warfarin  .

Adverse Reactions

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Further Reading

Publications

Other sources of information

  • Based onSmall Animal Formulary.Tennant Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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