Felis ISSN 2398-2950

Sucralfate

Introduction

Name

• Sucralfate.

Class of drug

• Mucosal protectant.
• Ulcer-healing agent.

Uses

Indications

• Esphageal, gastric and duodenal ulceration , usually with H2 antagonist (eg cimetidine   Cimetidine  ) but given separately.

Administration

Pharmacokinetics

Precautions

Interactions

with other drugs

H2 antagonists, phenytoin and tetracycline

• Sucralfate may decrease the bioavailability of H2 antagonists (eg cimetidine Cimetidine) and although there is little evidence to support that this is of clinical importance it may be a wise precaution to administer sucralfate at least 2 hours before these drugs.

Digoxin and flouroquinolones

• Sucralfate significantly interferes with the absorption of digoxin Digoxin and flouroquinolones.

Adverse Reactions