Felis ISSN 2398-2950

Sucralfate

Synonym(s): Antepsin

Introduction

Name

  • Sucralfate.

Class of drug

  • Mucosal protectant.
  • Ulcer-healing agent.

Uses

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Indications

  • Esphageal, gastric and duodenal ulceration , usually with H2 antagonist (eg cimetidine   Cimetidine  ) but given separately.

Administration

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Pharmocokinetics

Precautions

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Interactions

with other drugs

H2 antagonists, phenytoin and tetracycline
  • Sucralfate may decrease the bioavailability of H2 antagonists (eg cimetidine   Cimetidine  ) and although there is little evidence to support that this is of clinical importance it may be a wise precaution to administer sucralfate at least 2 hours before these drugs.
    Digoxin and flouroquinolones
  • Sucralfate significantly interferes with the absorption of digoxin   Digoxin  and flouroquinolones.

Adverse Reactions

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Further Reading

Publications

Other sources of information

  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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