Felis ISSN 2398-2950

Streptomycin

Contributor(s): Lauren Trepanier

Introduction

Name

  • Streptomycin.

Class of drug

  • Aminoglycoside antibiotic.

Uses

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Indications

  • An aminoglycoside antibiotic which is active against a wide range of gram-negative and some gram-positive pathogens.
  • Indicated in the treatment of infections caused by organisms sensitive to streptomycin, in particularLeptospirosaspp andMycobacterium tuberculosis  Mycobacterium tuberculosis  .
  • However, its use is limited because of its ototoxicity.
  • Aminoglycosides require an oxygen rich environment to be effective, thus they are ineffective in low oxygen sites (abscesses, exudates).
    All obligate anaerobes are resistant.

Administration

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Precautions

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Interactions

with other drugs

Cephalosporins (notably cephalothin)
  • There is an increased risk of nephrotoxicity.

Cytotoxic drugs

  • There is an increased risk of nephrotoxicity.

Cisplatin

  • Ototoxicity is increased.

Loop diuretics

  • Ototoxicity is increased.

Neostigmine and pyridostigmine

  • May be antagonized by aminoglycosides.

Non-depolarizing muscle relaxants (eg tubocurarine)

  • Effect may be enhanced by streptomycin.

Penicillin

  • Synergistic action, however, their pharmacokinetics differ, and thus the use of such compound preparations is generally thought to be unjustified.

Beta-lactam antibiotics (eg penicillins, cephalosporins)

  • May be inactivated when mixedin vitro.

Heparin

  • May be inactivated when mixedin vitro.

Adverse Reactions

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Further Reading

Publications

Other sources of information

  • Based on Tennant B (1999)Small Animal Formulary.3rd edn. Cheltenham: BSAVA.

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