Felis ISSN 2398-2950

Spironolactone

Contributor(s): Mark Rishniw, Vetstream Ltd

Introduction

Name

  • Spironolactone.

Class of drug

  • Potassium-sparing diuretic.

Description

Chemical name

  • 17-hydroxy-7alpha-mercapto-3-oxo-17alpha-pregn-4-ene-21-carboxylic acid-alpha-lactone.

Uses

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Indications

  • Particularly useful in the treatment of edema associated with congestive heart failure   Heart: congestive heart failure  (when hypokalemia may potentiate digoxin toxicity) and hepatic failure   Liver: cirrhosis  (when hypokalemia can precipitate hepatic encephalopathy   Hepatic encephalopathy  ).
  • Used in combination diuretic therapy (with thiazides and furosemide).

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs

ACE inhibitors, eg captopril, enalapril

  • Hyperkalemia may result.

NSAIDs

  • Hyperkalemia may result.
  • There is an increased risk of nephrotoxicity.

Potassium supplements

  • Hyperkalemia may result.

Digoxin

  • May increase half-life of digoxin.
  • The effect of digoxin may be enhanced.

with diagnostic tests

  • Electrolyte imbalances should be monitored.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • BSAVA Small Animal Formulary. Ramsey I (2017) 9th edn. Cheltenham: BSAVA.

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