ISSN 2398-2950      

Sotalol

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Introduction

Name

  • Sotalol.

Class of drug

  • Anti-arrhythmic (non-selective ß-adrenergic blocking drug with potassium channel blocking effects - classified as type III anti-arrhythmic under the Vaughan Williams classification).

Description

Chemical name

  • Sotalol HCL (racemic mixture of d-and l-stereo-isomers).

Physical properties

  • White crystalline solid.
  • Soluble in water.

Storage requirements

  • Store at room temperature.

Uses

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Indications

  • Used most commonly for the treatment of ventricular tachycardias in dogs and the treatment of Boxers with severe ventricular tachycardias and syncope.
  • Other indications may include the management of supraventricular tachycardias including atrioventricular nodal independent supraventricular tachycardia and atrioventricular reciprocating tachycardia associated with atrioventricular accessory pathways.
  • Atrial fibrillation and atrial flutter.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from VetMed Resource and PubMed.
  • Schober K E, Kent A M, Aeffner F (2014) Tachycardia-induced cardiomyopathy in a cat. Schweiz Arch Tierheilkd 156 (3), 133-139 PubMed.
  • Ferasin L (2009) Recurrent syncope associated with paroxysmal supraventricular tachycardia in a Devon Rex cat diagnosed by implantable loop recorder. J Feline Med Surg 11(2), 149-152 PubMed.
  • Meurs K M et al (2002) Comparison of the effects of four antiarrhythmic treatments for familial ventricular arrhythmias in Boxers. J Am Vet Med Assoc 221(4), 522 - 527 PubMed.

Other sources of information

  • Ramsey I (ed) (2017) BSAVA Small Animal Formulary. 9th edn. BSAVA, Gloucester. p364.
  • Moise S N (2002) Chronic management of tachyarrhythmias in the dog. Proceedings from the 26th Annual Waltham Symposium.
  • Plumb D C (2002) Veterinary Drug Handbook. Fourth Edition. Pharma Vet Publishing, Minnesota
  • Wright K N (2000) Assessment and Treatment of Supraventricular tachyarrhythmias. In: Kirk's Current Veterinary Therapy XIII - Sm Anim Pract 726 - 730.
  • Braunwald E, Zipes D P & Libby P (2001) Heart Disease: A Textbook of Cardiovascular Medicine. 6th Edn W B Saunders Co, Philadelphia.
  • Fox P R, Sisson D & Moise N S (1999) Textbook of Canine and Feline Cardiology: principles and clinical practice. 2nd edn. W B Saunders Co, Pennsylvania.
  • Kittleson M D & Kienle R D (1998) Small Animal Cardiovascular Medicine. Mosby, St Louis.
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