Felis ISSN 2398-2950

Silybin

Synonym(s): Silibin, silybinin, silibinin

Contributor(s): David C Twedt

Introduction

Name

  • Silybin.

Class of drug

  • Nutraceutical.
  • Nutritional supplement.
  • An active constituent of the extract silymarin from the milk thistle plantSilybum marianum.
  • A flavonolignan.

Description

Chemical name

  • Silybin A+B.

Molecular formula

  • C25H22O10.

Molecular weight

  • 482.44 g/mol.

Physical properties

  • A crystalline solid.

Storage requirements

  • Store in a cool, dry place.

Uses

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Indications

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs

  • None reported.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references fromPubMed.
  • Au A Y, Hasenwinkel J M, & Frondoza C G (2011)Silybin inhibits interleukin-1ß-induced production of pro-inflammatory mediators in canine hepatocyte cultures.J Vet Pharmacol Ther34(2), 120-129PubMed.
  • Al-Anati L, Essid E, Reinehr R, & Petzinger E (2009)Silibinin protects OTA-mediated TNF-alpha release from perfused rat livers and isolated rat Kupffer cells.Mol Nut Food Res53(4), 460-466.
  • Webb C B, McCord K W, & Twedt D C (2009)Assessment of oxidative stress in leukocytes and granulocyte function following oral administration of a silibinin-phosphatidylcholine complex in cats.Am J Vet Res70, 57-62.
  • Crocenzi F A & Roma M G (2006)Silymarin as a new hepatoprotective agent in experimental cholestasis: new possibilities for an ancient medication.Curr Med Chem13(9), 1055-1074.
  • Crocenzi F A, Sánchez Pozzi E J, Pelligrino J M, Rodríguez Garay E A, Mottino A D, & Roma M G (2003)Preventive effect of silymarin against taurolithocholate-induced cholestasis in the rat.Biochem Pharmacol66(2), 355-364.
  • Crocenzi F A, Pelligrino J M, Sánchez Pozzi E J, Mottino A D, Rodríguez Garay E A, & Roma M G (2000)Effect of silymarin on biliary bile salt secretion in the rat.Biochem Pharmacol59(8), 1015-1022.
  • Dehmlow C, Erhard J, & de Groot H (1996)Inhibition of Kupffer cell functions as an explanation for the hepatoprotective properties of silibinin.Hepatology23(4), 749-754.
  • Dehmlow C, Murawski N, & de Groot (1996)Scavenging of reactive oxygen species and inhibition of arachidonic acid metabolism by silibinin in human cells.Life Sci58(18), 1591-1600.
  • Filburn C R, Kettenacker R, & Griffin D W (2007)Bioavailability of a silybin-phosphatidylcholine complex in dogs.J Vet Pharmacol Ther30(2), 132-138PubMed.
  • Webb C B, Gustafson D L, & Twedt D C (2012)Bioavailability following oral administration of a silybinin-phosphatidylcholine complex in cats.Intern J Appl Res Vet Med20(2), 107-112.
  • Vogel G, Tuchweber B, Trost W, & Mengs U (1984)Protection by silibinin against Amanita phalloides intoxication in beagles.Toxicol App Pharmacol73(3), 355-362.

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