Felis ISSN 2398-2950

Selegiline hydrochloride

Synonym(s): L-deprenyl

Introduction

Name

  • Selegiline.

Class of drug

  • Alpha-2-agonist.

Uses

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Indications

  • Treatment of feline cognitive dysfunction.
  • Treatment of behavioral disorders of emotional origin such as depression and anxiety.
  • In association with behavioral therapy for treatment of signs of emotional origin observed in behavioral conditions eg overactivity, separation anxiety, phobias and unsociable behavior   Lack of appropriate socialization and/or habituation  .
  • In USA licensed for use in treatment of uncomplicated pituitary-dependent hyperadrenocorticism   Hyperadrenocorticism  (up to 50% cases may fail to respond).

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs

  • Discontinue at least for 24 hours before and after the use of other alpha-2-agonists for anesthesia or sedation.
  • Avoid tetracyclic antidepressants.
  • Avoid use with ephedrine or potential MAO inhibitors (eg Amitraz   Amitraz  ) or phenothiazines.
  • Should not be administered with pethidine   Pethidine  , fluoxetine   Fluoxetine hydrochloride  or tricyclic antidepressants (eg amitryptiline   Amitryptiline  , doxepin   Doxepin  , chlomipramine ).
  • The effect of morphine   Morphine  is potentiated when used simultaneously.

Adverse Reactions

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Further Reading


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