Felis ISSN 2398-2950

Rifampicin

Synonym(s): Rifampin

Contributor(s): Sally Anne Argyle, Jo Murrell

Introduction

Name

  • Rifampicin.

Class of drug

  • Rifampicin belongs to the class Rifamycin and is a bacteriocidal antibiotic that is a semi-synthetic derivative of the naturally occurring antibiotic rifamycin B.

Description

Chemical name

  • Rifampicin.

Molecular formula

  • C43H58N4O12

Molecular weight

  • 822.94

Uses

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Indications

  • It is particularly effective against Gram-positive organisms, some mycobacteria, Chlamydophila   Chlamydophila felis  ,Rickettsia, some protozoans and poxviruses   Cat pox virus  .
  • It is most commonly used to treatMycobacterium tuberculosis  Mycobacterium tuberculosis  ,Rhodococcus andStaphylococciinfections   Staphylococcus spp  .
  • Gram-negative aerobic bacteria are usually resistant to rifampicin but obligate anaerobic bacteria are usually susceptible.

Administration

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Pharmocokinetics

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Precautions

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Interactions

with other drugs

  • Rifampicin is a potent hepatic P450 cytochrome enzyme inducer and increases rate of metabolism of other drugs in man including barbiturates, theophylline   Theophylline   and ketoconazole   Ketoconazole  . Increased dosages of these drugs may be required if used in combination with rifampicin.

Adverse Reactions

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Further Reading

Publications

Refereed papers

  • Recent references fromPubMed
  • Riviere D, Pingret J-L, Etievant M, Jechoux A, Lanore D, Raymond-Letron I, Boucraut-Baralon (2011)Disseminated Mycobacterium avium subspecies infection in a cat.J Fel Med Surg13, 125-128PubMed.

Other sources of information

  • The Veterinary Formulary(2004) 6th edn. Ed: Bishop Y. British Veterinary Association and Royal Pharmaceutical Society.

ADDED