Felis ISSN 2398-2950

Quinidine

Introduction

Name

  • Quinidine.

Class of drug

  • Class 1a antiarrhythmic agent.

Uses

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Indications

  • It is used in the management of ventricular arrhythmias (VPC's)   Ventricular premature contraction  , refractory supraventricular tachycardias (with caution) and acute atrial fibrillation .

Administration

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Precautions

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Interactions

with other drugs

Digoxin
  • Digoxin levels may be increased by quinidine. It is recommended that the dose of digoxin be decreased by 1/2 when adding quinidine and that serum drug levels of both quinidine and digoxin be assessed.

  • Neuromuscular blockers (eg atracurium, suxamethonium, tubocurarine)
  • Effects may be enhanced by quinidine.

  • Drugs that alkalinize urine (eg antacids, carbonic anhydrase inhibitors, sodium bicarbonate, thiazide diuretics)
  • Reduce the excretion of quinidine, thus prolonging its half-life.

  • Phenobarbital or phenytoin
  • The half-life of quinidine may be reduced by as much as 50% as a consequence of hepatic enzyme induction by these drugs.

  • Cimetidine
  • Inhibits the metabolism of quinidine by inhibiting hepatic microsomal enzymes, thereby increasing its effect.

  • Antiarrhythmic drugs (eg procainamide)
  • Additive cardiac depressant effects and an increased risk of ventricular arrhythmias may result.

  • Verapamil
  • There is an increased risk of hypotension.

Adverse Reactions

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Further Reading

Publications

Other sources of information

  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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