Felis ISSN 2398-2950

Pyrimethamine

Contributor(s): Kyle Braund, Vetstream Ltd

Introduction

Name

  • Pyrimethamine.

Class of drug

  • Folate antagonist (similar to Frimeth opium) .

Uses

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Indications

  • Used in combinations with sulfonamides.
  • Infections caused byToxoplasma gondii  Toxoplasma gondii  andNeospora caninum.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

Phenytoin or sulfonamides

  • Increased anti-folate effect.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Thate F M & Laanen S C (1998) Successful treatment of neosporosis in an adult dog. Vet Q 20(Suppl 1), 5113-5114.
  • Barber J S & Trees A J (1996) Clinical aspects of 27 cases of neosporosis in dogs. Vet Rec 139(18), 439-443.

Other sources of information

  • BSAVA Small Animal Formulary. Ramsey I (2017) 9th edn. Cheltenham: BSAVA
  • Plumb D C (1999) Veterinary Drug Handbook. 3rd edn. Iowa State University Press. pp 556-558

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