Felis ISSN 2398-2950

Pyrimethamine

Contributor(s): Kyle Braund

Introduction

Name

  • Pyrimethamine.

Class of drug

  • Folate antagonist (similar to Frimeth opium) .

Uses

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Indications

  • Used in combinations with sulfonamides.
  • Infections caused byToxoplasma gondii  Toxoplasma gondii  andNeospora caninum.

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs

Phenytoin or sulfonamides
  • Increased anti-folate effect.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Thate F M & Laanen S C (1998)Successful treatment of neosporosis in an adult dog.Vet Q20(Suppl 1), 5113-5114.
  • Barber J S & Trees A J (1996)Clinical aspects of 27 cases of neosporosis in dogs.Vet Rec139(18), 439-443.

Other sources of information

  • Based on Tennant, B (1999)Small Animal Formulary.3rd edn. Cheltenham: BSAVA.
  • Plumb D C (1999)Veterinary Drug Handbook.3rd edn. Iowa State University Press. pp 556-558

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