Felis ISSN 2398-2950

Pyridostigmine

Synonym(s): Mestinon

Contributor(s): Kyle Braund

Introduction

Name

  • Pyridostigmine bromide.

Class of drug

  • Anticholinesterase (long-acting).

Uses

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Indications

  • Myasthenia gravis   Myasthenia gravis  (acquired and congenital forms).
  • Glucocorticoids   Prednisolone  or other immunosuppressants, eg azathioprine   Azathioprine  may provide effective adjunctive therapy. However, the use of glucocorticoids is controversial as they may decrease the effectiveness of pyridostigmine.

Administration

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Precautions

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Interactions

with other drugs

Aminoglycosides, clindamycin, lincomycin, polymyxins and propranolol
  • May antagonize the effect of pyridostigmine.

  • Suxamethonium
  • Pyridostigmine may enhance the effect.

  • Non-depolarizing muscle relaxants
  • Pyridostigmine may antagonize the effect.
  • Corticosteroids may decrease the anticholinesterase activity of pyridostigmine.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Dewey C Wet al(1999)Azathioprine therapy for acquired myasthenia gravis in five dogs.JAAHA35(5), 396-402.

Other sources of information

  • Based onSmall Animal Formulary.Tennant Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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