Felis ISSN 2398-2950

Prochlorperazine

Introduction

Name

  • Prochlorperazine.

Class of drug

  • Piperazine phenothiazine.
  • CNS dopamine receptor blocker.

Uses

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Indications

  • It is used predominantly to control motion sickness.

Administration

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Precautions

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Interactions

with other drugs

CNS depressant agents (eg anesthetics, narcotic analgesics)
  • May cause additive CNS depression.
    Quinidine
  • Given with phenothiazines may cause additive cardiac depression   Quinidine  .
    Antacids or antidiarrheal preparations (eg bismuth subsalicylate or kaolin/pectin mixtures)
  • May reduce gastrointestinal absorption of oral phenothiazines.
    Propranolol
  • Increased blood levels of both drugs may result if propranolol   Propranolol  is administered with phenothiazines.
    Epinephrine
  • Phenothiazines block alpha-adrenergic receptors which, may lead to unopposed beta activity causing vasodilation and increased cardiac rate.
    Phenytoin
  •   Phenytoin  Metabolism may be decreased if given concurrently with phenothiazines.

Adverse Reactions

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Further Reading

Publications

Other sources of information

  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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