ISSN 2398-2950      

Prochlorperazine

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Introduction

Name

  • Prochlorperazine.

Class of drug

  • Piperazine phenothiazine.
  • CNS dopamine receptor blocker.

Uses

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Indications

  • It is used predominantly to control motion sickness.

Administration

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Precautions

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Interactions

with other drugs

CNS depressant agents (eg anesthetics, narcotic analgesics)

  • May cause additive CNS depression.

Quinidine

  • Given with phenothiazines may cause additive cardiac depression Quinidine.

Antacids or antidiarrheal preparations (eg bismuth subsalicylate or kaolin/pectin mixtures)

  • May reduce gastrointestinal absorption of oral phenothiazines.

Propranolol

  • Increased blood levels of both drugs may result if propranolol Propranolol  is administered with phenothiazines.

Epinephrine

  • Phenothiazines block alpha-adrenergic receptors which, may lead to unopposed beta activity causing vasodilation and increased cardiac rate.

Phenytoin

  •   Metabolism may be decreased if given concurrently with phenothiazines Phenytoin.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Based on Small Animal Formulary. Tennant B (1999) 3rd edn. BSAVA, UK.
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