Felis ISSN 2398-2950

Primidone

Contributor(s): Kyle Braund

Introduction

Name

  • Primidone.

Class of drug

  • Barbiturate derivative.

Uses

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Indications

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs

Oral acetazolamide
  • May decrease the gastrointestinal (GI) absorption of primidone   Acetazolamide  .

  • As the primary active metabolite for primidone is phenobarbital the following drug interactions may be of clinical significance
  • Drugs increasing the effect of primidone:
  • Chloramphenicol   Chloramphenicol  .
  • Other central nervous system (CNS) depressants, eg antihistamines, narcotics, phenothiazines.
  • Valproic acid   Sodium valproate  .
  • Drugs affected by primidone (enhanced metabolism/decreased effect):
  • Griseofulvin:
  • Primidone may decrease absorption; avoid giving them together   Griseofulvin  .
  • Barbiturates:
  • May enhance the toxic effect of anti-epileptics.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Rambuck Bet al(1999)Concentrations of phenobarbital in epileptic dogs on phenobarbital or primidone therapy.Kleintierpraxis44(5), 345-354.
  • Trepanier L Aet al(1998)Therapeutic serum drug concentrations in epileptic dogs treated with potassium bromide alone or in combination with other anticonvulsants - 122 cases (1992-1996).JAVMA213(10), 1449-1453.

Other sources of information

  • Based onSmall Animal Formulary.Tennant Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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