ISSN 2398-2950      

Primidone

ffelis
Contributor(s):

Kyle Braund


Introduction

Name

  • Primidone.

Class of drug

  • Barbiturate derivative.

Uses

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Indications

Administration

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Pharmacokinetics

Precautions

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Interactions

with other drugs

Oral acetazolamide
  • May decrease the gastrointestinal (GI) absorption of primidone   Acetazolamide  .

  • As the primary active metabolite for primidone is phenobarbital the following drug interactions may be of clinical significance
  • Drugs increasing the effect of primidone:
  • Chloramphenicol   Chloramphenicol  .
  • Other central nervous system (CNS) depressants, eg antihistamines, narcotics, phenothiazines.
  • Valproic acid   Sodium valproate  .
  • Drugs affected by primidone (enhanced metabolism/decreased effect):
  • Griseofulvin:
  • Primidone may decrease absorption; avoid giving them together   Griseofulvin  .
  • Barbiturates:
  • May enhance the toxic effect of anti-epileptics.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Rambuck B et al (1999) Concentrations of phenobarbital in epileptic dogs on phenobarbital or primidone therapy. Kleintierpraxis 44 (5), 345-354.
  • Trepanier L A et al (1998) Therapeutic serum drug concentrations in epileptic dogs treated with potassium bromide alone or in combination with other anticonvulsants - 122 cases (1992-1996). JAVMA 213 (10), 1449-1453.

Other sources of information

  • Based on Small Animal Formulary. Tennant B (1999) 3rd edn. BSAVA, UK.
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