Felis ISSN 2398-2950

Prazosin

Synonym(s): Hypovase

Contributor(s): Mark Rishniw

Introduction

Name

  • Prazosin.

Class of drug

  • Alpha-1 adrenoceptor blocker.
  • Vasodilator.

Description

Chemical name

  • 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furoyl)piperazine HCl.

Molecular formula

  • C19H21N5O4.HCl.

Molecular weight

  • 419.87.

Physical properties

  • White powder.

Uses

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Indications

  • Urethral relaxation with obstructive urinary disease.
  • CHF   Heart: congestive heart failure  , although it loses its effectiveness with prolonged use.
  • It may be useful in promoting urine flow in patients with benign prostatic hyperplasia .
  • May be useful in the management of hypertension associated with cardiac or renal disease.
  • Not used commonly in cats.

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs

Beta-blockers, eg propranolol/diuretics, eg furosemide/calcium channel blockers
  • May increase the risk of a first-dose hypotensive effect.

Adverse Reactions

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Further Reading

Publications

Other sources of information

  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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