Felis ISSN 2398-2950

Phenobarbital

Synonym(s): Epiphen, Phenobarbitone

Contributor(s): Kyle Braund

Introduction

Name

  • Phenobarbital sodium.

Class of drug

Uses

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Indications

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs

Drugs increasing effect of phenobarbital

Drugs affected by phenobarbital (enhanced metabolism/decreased effect)

Griseofulvin

  • Phenobarbital may decrease absorption; avoid giving them together Griseofulvin.

Anti-epileptics

  • Barbiturates may enhance the effect of other anti-epileptics.
  • Phenobarbital reduces total plasma benzodiazepine concentration (IV and per rectum administration).
  • Serum total and free T4 concentrations may be low, ie in the range typical for dogs with hypothyroidism in dogs treated with phenobarbital.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from VetMed Resource and PubMed.
  • Lord L K & Pedell M (1999) Owner perception of the care of long-term phenobarbital treated epileptic dogs. JSAP 40(1), 11-15.
  • Kantrowitz L B et al (1999) Serum total thyroxine, total triiodo thyronine, free thyroxine, and thyrotropin concentrations in epileptic dogs treated with anticonvulsants. JAVMA 214(12), 1804-1808.
  • Rambeck B et al (1999) Concentrations of phenobarbital in epileptic dogs on phenobarbital or primidone therapy. Kleintier Praxis 44(5), 345-354.
  • Wagner S O et al (1998) Chronic phenobarbital therapy reduces plasma benzodiazepine concentrations after intravenous and rectal administration of diazepam in the dog.  Vet Pharm Therap 21(5), 335-341.

Other sources of information

  • Based on Small Animal Formulary. Tennant Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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