Felis ISSN 2398-2950

Pethidine

Synonym(s): meperidine HCl, Demerol

Contributor(s): Kyle Braund

Introduction

Name

  • Pethidine.

Class of drug

  • Opioid analgesic.
  • Schedule II Controlled Substance

Uses

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Indications

  • A narcotic analgesic which provides prompt but short-term analgesia   Analgesia: overview  ; onset of action of 10-15 minutes and duration of 2-3 hours.
  • Less potent than morphine   Morphine  in its analgesic and respiratory depressant effects.
  • Pethidine is preferred to morphine for control of pain with pancreatitis   Pancreatitis  .

Administration

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Precautions

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Interactions

with other drugs

Central nervous system (CNS) depressants (anesthetics, antihistamines, barbiturates, phenothiazines, tranquilizers)
  • Increased CNS or respiratory depression.

Cimetidine

  • The metabolism of pethidine is inhibited thereby increasing plasma concentrations   Cimetidine  .

with diagnostic tests

Plasma amylase and lipase
  • As narcotic analgesics may increase biliary tract pressure, levels may be increased for up to 24 hours after narcotic administration (increased biliary tract pressure).

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Slingsby LS & Waterman-Pearson AE (1998)Comparison of pethidine, buprenorphine and ketoprofen for postoperative analgesia after ovariohysterectomy in the cat.Vet Rec.143(7), 185-189.
  • Balmer TVet al(1998)Comparison of carprofen and pethidine as postoperative analgesics in the cat.J Small Anim Pract.39(4), 158-164.

Other sources of information

  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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