ISSN 2398-2950      

Pethidine

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Synonym(s): meperidine HCl, Demerol


Introduction

Name

  • Pethidine.

Class of drug

Uses

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Indications

  • A narcotic analgesic which provides prompt but short-term analgesia Analgesia: overview; onset of action of 10-15 minutes and duration of 2-3 hours.
  • Less potent than morphine Morphine in its analgesic and respiratory depressant effects.
  • Pethidine is preferred to morphine for control of pain with pancreatitis Pancreatitis.

Administration

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Precautions

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Interactions

with other drugs

Central nervous system (CNS) depressants (anesthetics, antihistamines, barbiturates, phenothiazines, tranquilizers)

  • Increased CNS or respiratory depression.

Cimetidine

  • The metabolism of pethidine is inhibited thereby increasing plasma concentrations Cimetidine.

with diagnostic tests

Plasma amylase and lipase

  • As narcotic analgesics may increase biliary tract pressure, levels may be increased for up to 24 hours after narcotic administration (increased biliary tract pressure).

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Slingsby L S & Waterman-Pearson A E (1998) Comparison of pethidine, buprenorphine and ketoprofen for postoperative analgesia after ovariohysterectomy in the cat. Vet Rec 143 (7), 185-189.
  • Balmer T V et al (1998) Comparison of carprofen and pethidine as postoperative analgesics in the cat. J Small Anim Pract 39 (4), 158-164.

Other sources of information

  • BSAVA Small Animal Formulary. Ramsey I (2017) 9th edn. BSAVA, UK.
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