Felis ISSN 2398-2950

Penicillamine

Introduction

Name

  • Penicillamine.

Class of drug

  • Oral chelating agent.

Uses

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Indications

  • Used in humans for the treatment of rheumatoid arthritis (mechanism unknown).
  • In dogs it has been used mainly for treating copper-associated hepatopathy in the Bedlington Terrier and the oral treatment of lead poisoning   Lead toxicity  .
  • It has also been used in the treatment of primary biliary cirrhosis, idiopathic chronic active hepatitis and cystinuria (decreases cystine excretion by combining with cystine to form the soluble complex cystine-D-penicillamine disulfide).
  • May also be used in the management of lead toxicity in birds when injecting EDTA is too difficult or long term chelation is required.

Administration

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Pharmocokinetics

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Precautions

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Interactions

with other drugs

Drugs decreasing the absorption of penicillamine
  • Antacids   Aluminum antacid  .
  • Iron   Iron  .
  • Zinc salts.
    Cytotoxic drugs
  • An increase in the renal and hematologic effects of penicillamine have been recorded in people.
    Gold
  • An increase in the renal and hematologic effects of penicillamine have been recorded in people.
    Phenylbutazone
  • An increase in the renal and hematologic effects of penicillamine have been recorded in people.   Phenylbutazone 

Adverse Reactions

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Further Reading

Publications

Other sources of information

  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.

ADDED