ISSN 2398-2950      

Penicillamine

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Introduction

Name

  • Penicillamine.

Class of drug

  • Oral chelating agent.

Uses

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Indications

  • Used in humans for the treatment of rheumatoid arthritis (mechanism unknown).
  • In dogs it has been used mainly for treating copper-associated hepatopathy in the Bedlington Terrier and the oral treatment of lead poisoning   Lead toxicity  .
  • It has also been used in the treatment of primary biliary cirrhosis, idiopathic chronic active hepatitis and cystinuria (decreases cystine excretion by combining with cystine to form the soluble complex cystine-D-penicillamine disulfide).
  • May also be used in the management of lead toxicity in birds when injecting EDTA is too difficult or long term chelation is required.

Administration

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Pharmacokinetics

Precautions

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Interactions

with other drugs

Drugs decreasing the absorption of penicillamine Cytotoxic drugs
  • An increase in the renal and hematologic effects of penicillamine have been recorded in people.
Gold
  • An increase in the renal and hematologic effects of penicillamine have been recorded in people.
Phenylbutazone
  • An increase in the renal and hematologic effects of penicillamine have been recorded in people.  

Adverse Reactions

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Further Reading

Publications

Refereed Papers

Other sources of information

  • Based on Small Animal Formulary. Tennant B (1999) 3rd edn. BSAVA, UK.
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