Felis ISSN 2398-2950

Pancuronium

Contributor(s): John Dodam

Introduction

Name

  • Pancuronium.

Class of drug

  • Non-depolarizing neuromuscular blocking agent.

Uses

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Indications

  • Profound skeletal muscle relaxation when modest cardiovascular stimulation required.
  • In patients undergoing mechanical ventilation.

Administration

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Pharmocokinetics

Precautions

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Interactions

with other drugs

Drugs which may antagonize the effects of pancuronium
  • Acetylcholine.
  • Aminoglycosides.
  • Anticholinesterases (pyridostigmine, neostigmine).
  • Azlocillin.
  • Azathioprine.
  • Clindamycin.
  • Lincomycin.
  • Polymyxin.
  • Potassium - low potassium may enhance effects.
  • Theophylline.

Suxamethonium

  • May enhance muscular relaxation (delay the administration of pancuronium until the effects of suxamethonium begin to diminish).

Drugs which may enhance the action of pancuronium

  • Some antibiotics, eg aminoglycosides, clindamycin, lincomycin.
  • Inhalational anesthetics, eg halothane, methoxyflurane.
    Duration of action is longer when isoflurane rather than halothane is used to maintain anesthesia.
  • Magnesium salts.
  • Quinidine.

Adverse Reactions

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Further Reading

Publications

Other sources of information

  • Based onSmall Animal Formulary.Tennant Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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