Felis ISSN 2398-2950

Oxytetracycline

Introduction

Name

• Oxytetracycline.

Class of drug

• Tetracycline antibiotic.

Description

Chemical name

• [4S-(4-alpha,4a-alpha,5-alpha,5a-alpha,6-beta,12a-alpha)]-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide.

Molecular formula

• C22H24N2O9.

Physical properties

• Aqueous solution.
• Tablets.

Storage requirements

• <25°C.
• Protect from light.

Uses

Indications

• Inhibits the growth of many gram-positive and gram-negative bacteria, rickettsiae, mycoplasma, spirochetes and other microbes.

Administration

Pharmacokinetics

Precautions

Interactions

with other drugs

Penicillins

• The bactericidal action of the penicillins may be inhibited by oxytetracycline.

Drugs decreasing absorption by binding to tetracycline

• Antacids containing divalent or trivalent cations (Mg, Ca, Al).
• Iron.
• Sodium bicarbonate.

Digoxin

• The availability may be increased by tetracyclines for months after their discontinuation leading to digoxin toxicity.

Anticoagulants

• Plasma prothrombin activity may be reduced by tetracyclines and therefore patients on anticoagulant therapy may need a dose adjustment.

Methoxyflurane

• Tetracyclines may increase the nephrotoxic effects.

Theophyllines

• The GI effects of tetracyclines may be increased.

Adverse Reactions