ISSN 2398-2950      

Oxytetracycline

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Introduction

Name

  • Oxytetracycline.

Class of drug

  • Tetracycline antibiotic.

Description

Chemical name

  • [4S-(4-alpha,4a-alpha,5-alpha,5a-alpha,6-beta,12a-alpha)]-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide.

Molecular formula

  • C22H24N2O9.

Physical properties

  • Aqueous solution.
  • Tablets.

Storage requirements

  • <25°C.
  • Protect from light.

Uses

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Indications

  • Inhibits the growth of many gram-positive and gram-negative bacteria, rickettsiae, mycoplasma, spirochetes and other microbes.

Administration

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Pharmacokinetics

Precautions

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Interactions

with other drugs

Penicillins

  • The bactericidal action of the penicillins may be inhibited by oxytetracycline.

Drugs decreasing absorption by binding to tetracycline

  • Antacids containing divalent or trivalent cations (Mg, Ca, Al).
  • Iron.
  • Sodium bicarbonate.

Digoxin

  • The availability may be increased by tetracyclines for months after their discontinuation leading to digoxin toxicity.

Anticoagulants

  • Plasma prothrombin activity may be reduced by tetracyclines and therefore patients on anticoagulant therapy may need a dose adjustment.

Methoxyflurane

  • Tetracyclines may increase the nephrotoxic effects.

Theophyllines

  • The GI effects of tetracyclines may be increased.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • McGrotty Y L & Knottenbelt C M (2002) Oesophageal stricture in a cat due to oral administration of tetracyclines. J Small Anim Pract 43 (5), 221-223.
  • Watson A D (1992) Bioavailability and bioinequivalence of drug formulations in small animals. J Vet Pharmacol Ther 15 (2), 151-159.
  • Riond J L, Vaden S L & Riviere J E (1990) Comparative pharmacokinetics of doxycycline in cats and dogs. J Vet Pharmacol Ther 13 (4), 415-424.
  • Schwarz S, Roberts M C, Werckenthin C, Pang Y & Lange C (1998) Tetracycline resistance in Staphylococcus spp. from domestic animals. Vet Microbiol 63 (2-4), 217-227.

Other sources of information

  • Ramsey I (2017) BSAVA Small Animal Formulary. 9th edn.
  • Based on Small Animal Formulary. Tennant B (1999) 3rd edn. BSAVA, UK. ISBN: 0 9052 1452 8.
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