Felis ISSN 2398-2950

Neomycin

Synonym(s): Framycetin

Contributor(s): Lauren Trepanier

Introduction

Name

  • Neomycin.

Class of drug

  • Aminoglycoside antibiotic.

Uses

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Indications

  • Gram-negative infections.
  • Some staphylococcal and streptococcal (fecalis) infections.
    All obligate anaerobic bacteria and many hemolytic streptococci are resistant.
  • As neomycin is extremely nephrotoxic and ototoxic it isprimarily used topically for infections of skin, ear or mucous membranes, or orally to reduce intestinal bacterial population in treating hepatic encephalopathy and before intestinal surgery.
    • Non-specific bacterial enteritides - often in combination with antimuscarinic agents.
    • Treatment of hepatic encephalopathy (coma) together with dietary protein reduction and lactulose: 20mg/kg PO QID, or 10-20 mg/kg in water as a retention enema.
    • To reduce bacterial flora before elective colorectal surgery (along with appropriate bowel evacuation): 500mg-1g (with an identical dose of erythromycin base) 19 hours, 18 hours and 9 hours before surgery.

    This dosage regimen is derived from human data. Differences in gastrointestinal (GI) transit times may alter the dosing schedule in dogs.

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs

Drugs affected by neomycin (decreased absorption)
  • Digoxin.
  • Methotrexate.
  • Penicillin V.
  • Potassium.
  • Vitamin K.

Ototoxic and nephrotoxic drugs (eg furosemide, gentamicin and polymyxin B)

  • Increased risk of toxicity.

Adverse Reactions

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Further Reading

Publications

Other sources of information

  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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