Felis ISSN 2398-2950

Naloxone

Synonym(s): Naloxone HCl

Contributor(s): Kyle Braund

Introduction

Name

  • Naloxone.

Class of drug

  • Opioid antagonist.

Uses

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Indications

  • Indicated for treatment of gross overdosage of all narcotic including agonist/antagonists (eg butorphanol, nalbuphine).
  • Has been used in the management shock (high doses).
  • To identify persistent opioid activity ( a small IV dose will give transient increase in consciousness when persistent opioid activity contributes to prolonged anesthetic recovery).

Administration

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Precautions

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Interactions

with other drugs

Narcotics
  • The narcotic effects may persist longer than that of naloxone, therefore monitor animals being treated for overdose carefully, until the narcotic effects remain negated.
  • Naloxone will also reverse the analgesic effects of narcotics.

Further Reading

Publications

Other sources of information

  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.
  • Plumb DC (1999)Veterinary Drug Handbook.3rd edn. Iowa State University Press, Ames. pp 445-446.

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