Felis ISSN 2398-2950

Mycophenolate mofetil

Synonym(s): MMF

Contributor(s): Vetstream Ltd, Gigi Davidson

Introduction

Name

  • Mycophenolate mofetil.

Class of drug

  • Immunosuppressant.

Description

Chemical name

  • 2-morpholinoethyl (E)-6-(1,3-­dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4­-hexenoate

Molecular formula

  • C23H31NO7

Molecular weight

  • 433.50

Physical properties

  • Oral: 250 mg capsules, 500 mg tablets,1 g/5 ml powder for oral suspension; 180 mg, 360 mg tablets.
  • Injectable: 500 mg powder for reconstitution and slow IV infusion.

Storage requirements

  • Capsules, tablets and injections: 25°C. Discard reconstituted injection after 7 days.
  • Reconstituted oral suspension: 4°C or 25°C. Discard reconstituted suspension after 60 days.

Uses

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Indications

Administration

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Pharmocokinetics

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Precautions

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Interactions

With other drugs

  • Competes with other drugs that undergo active renal tubular secretion resulting in increased concentration of either drug.
  • Concomitant administration of antacids (eg omeprazole Omeprazole) may decrease absorption.
  • May interfere with antibody response to vaccination.

With diagnostic tests

  • May elevate blood glucose concentrations.

Adverse Reactions

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Further Reading

Publications

Refereed Papers

  • Recent references from VetMed Resource and PubMed.
  • Slovak J E & Villarino N F (2018) Safety of oral and intravenous mycophenolate mofetil in healthy cats. J Feline Med Surg 20(2), 184-188 PubMed.
  • Downing H J, Pirmohamed M, Beresford M W, Smyth R L (2013) Paediatric use of mycophenolate mofetil. Br J Clin Pharmacol 75(1), 45-59 PubMed.
  • Viviano K R (2013) Update on imunosuppressive therapies for dogs and cats. Vet Clin North Am Small Anim Pract 43(5), 1149-1170 PubMed.
  • Bacek L M & Macintire D K (2011) Treatment of primary immune-mediated hemolytic anemia with mycophenolate mofetil in two cats. J Vet Emerg Crit Care (San Antonio) 21(1), 45-49 PubMed.

Other sources of information

  • Ramsey I (2017) BSAVA Small Animal Formulary. 9th edn BSAVA: Gloucester.

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