Felis ISSN 2398-2950

Moxidectin

Synonym(s): Advocate®, Advantage® Multi

Contributor(s): Linda Horspool

Introduction

Name

  • CAS.

Class of drug

  • A milbemycin, member of the macrocyclic lactone (macrolide) antimicrobial class.

Description

Chemical name

  • (2aE,4E,8E)-(52S,6R,62S,11R,13R,15S,17aR,20R,20aR,20bS)-62-[(1E)-1,3-dimethylbut-1-enyl]-52,62,10,11,14,15,17a,20,20a,20b-decahydro-20,20b-dihydroxy-52,6,8,19-tetramethylspiro[11,15-methano-2H,13H,17H-furo[4,3,2-pq][2,6]benzodioxacyclooctadecin-13,22-[2H]pyran]-42,17(32H,6H)-dione 42-(E)-(O-methyloxime).

Molecular formula

  • C37H53NO8

Molecular weight

  • 639.84

Physical properties

  • Water Solubility (at 25 °C, pH 7): 51 ppb.
  • Octanol-water Partition Coefficient: 58.3.
  • Photolysis half-life:  6.8 hours.
  • Finished product:
    • Spot-on solution.
    • A clear, yellow to brownish solution.

Storage requirements

  • Product as packaged for sale: Do not store above 30 °C.

Uses

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Indications

  • Endectocide - activity against endo- and ectoparasites.
  • Broad spectrum of activity in dogs, cats and ferrets including:
    • Gastrointestinal nematodes.
    • Developmental stages of filarial nematodes (egDirofilaria immitis  Dirofilaria immitis  ).
    • Arachnids, such as mites.

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs

  • No other antiparasitic macrocyclic lactone should be administered concurrently. 
  • No interactions with routinely used veterinary medicinal products or medical or surgical procedures have been observed. 

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references fromVetMedResourceandPubMed.
  • Janko C, Geyer J (2013)Moxidectin has a lower neurotoxic potential but comparable brain penetration in P-glycoprotein-deficient CF-1 mice compared to ivermectin.J Vet Pharmacol Ther36, 275-284 PubMed.
  • Taweethavonsawat P, Chungpivat S, Watanapongchati S, Traub RJ, Schaper R (2012)Efficacy of a spot on combination containing imidacloprid 10% and moxidectin 1% (Advocate(®)/Advantage(®) Multi, Bayer Animal Health) against Ancylostoma ceylanicum in cats.Vet Parasitol190, 289-293 PubMed.
  •  Hellmann K, Knoppe T, Radeloff I, Heine J (2003)The anthelmintic efficacy and the safety of a combination of imidacloprid and moxidectin spot-on in cats and dogs under field conditions in Europe.Parasitol Res90Suppl 3, S142-143 PubMed.
  • von Samson-Himmelstjerna G, Epe C, Schimmel A, Heine J (2003)Larvicidal and persistent efficacy of an imidacloprid and moxidectin topical formulation against endoparasites in cats and dogs.Parasitol Res90Suppl 3, S114-115 PubMed.

Other sources of information


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