Felis ISSN 2398-2950

Morphine

Synonym(s): morphine sulfate

Contributor(s): Kyle Braund, John Dodam, Sheilah Robertson

Introduction

Name

  • Morphine.

Class of drug

  • Opioid analgesic.
  • Schedule II Controlled Substance.
  • Mu receptor agonist.

Description

Chemical name

  • (5-alpha,6-alpha)-7,8-didehydro-4,5-epoxy-17-methylmorphinan-3,6-diol

Molecular formula

  • C17H19NO3

Physical properties

  • Tablets.
  • Solution.

Uses

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Indications

  • A narcotic analgesic used primarily as a pre-anesthetic agent   Anesthetic premedication: overview  .
  • Peri-operative and severe traumatic pain relief.
  • Extradural analgesia.
  • Intraarticular analgesia.

Administration

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Precautions

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Interactions

with other drugs

CNS depressants (anesthetics, antihistamines, barbiturates, phenothiazines, tranquilizers)
  • Enhanced central nervous system (CNS) or respiratory depression may occur.

with diagnostic tests

Plasma amylase or lipase
  • As narcotic analgesics can increase biliary tract pressure, levels may be increased for up to 24 hours after drug administration.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Jones RS (2001)Epidural analgesia in the dog and cat.Vet J.161(2), 123-131.
  • Dohoo SE & Dohoo IR (1998)Attitudes and concerns of Canadian animal health technologists toward postoperative pain management in dogs and cats.Can Vet J.39(8), 491-496.

Other sources of information

  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.
  • Plumb DC (1999)Veterinary Drug Handbook.3rd edn. Iowa State University Press, Ames. pp 440-443

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