ISSN 2398-2950      

Midazolam

ffelis
Contributor(s):

Kyle Braund

Jo Murrell


Introduction

Name

  • Midazolam.

Class of drug

Uses

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Indications

  • Preoperative sedative agent.
  • Unreliable sedation on its own, although it will sedate depressed animals.
  • Midazolam has very few hypotensive effects.
  • Midazolam has good cardiovascular stability.

Administration

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Precautions

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Interactions

with other drugs

Antihistamines, barbiturates, opioid analgesics, or other central nervous system depressants

  • Concurrent use may enhance the sedative effect.

Opioid analgesics (eg pethidine)

  • May increase the hypnotic and hypotensive effects of midazolam.
  • Midazolen has very few hypotensive effects.
  • Midazolen has good cardiovascular stability.

Inhalational anesthetics

  • Decrease the dosages required.

Erythromycin

  • Inhibits the metabolism of midazolam.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from VetMedResource and PubMed.
  • Lagos-Carvajal A, Queiroz-Williams P, da Cunha A, Liu CC (2019) Determination of midazolam dose for co-induction with alfaxalone in sedated cats. Vet Anaesth Analg 46 (3), 299-307 PubMed
  • Robinson R, Borer-Weir K (2015) The effects of diazepam or midazolam on the dose of propofol required to induce anaesthesia in cats. Vet Anaesth Analg 42 (5), 493-501 PubMed
  • Cruz M L, Luna S P, de Castro G B, Massone F & Rosa A L (2000) A preliminary trial comparison of several anesthetic techniques in cats. Can Vet J 41 (6), 481-485.

Other sources of information

  • Based on Small Animal Formulary. Tennant B (1999) 3rd edn. BSAVA, UK.
  • Plumb D C (1999) Veterinary Drug Handbook. 3rd edn. Iowa State University Press, USA. pp 429-431.
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