Felis ISSN 2398-2950

Midazolam

Contributor(s): Kyle Braund

Introduction

Name

  • Midazolam.

Class of drug

Uses

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Indications

  • Preoperative sedative agent.
  • Unreliable sedation on its own, although it will sedate depressed animals.

Administration

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Pharmocokinetics

Precautions

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Interactions

with other drugs

Antihistamines, barbiturates, opioid analgesics, or other central nervous system depressants

  • Concurrent use may enhance the sedative effect.

Opioid analgesics (eg pethidine)

  • May increase the hypnotic and hypotensive effects of midazolam.
  • Midazolen has very few hypotensive effects.
  • Midazolen has good cardiovascular stability.

Inhalational anesthetics

  • Decrease the dosages required.

Erythromycin

  • Inhibits the metabolism of midazolam.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from VetMed Resource and PubMed.
  • Cruz M L, Luna S P, de Castro G B, Massone F & Rosa A L (2000) A preliminary trial comparison of several anesthetic techniques in cats. Can Vet J 41(6), 481-485.

Other sources of information

  • Based on Small Animal Formulary. Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.
  • Plumb DC (1999) Veterinary Drug Handbook. 3rd edn. Iowa State University Press, Ames. pp 429-431.

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