Felis ISSN 2398-2950

Mexiletine

Introduction

Name

  • Mexiletine.

Class of drug

  • Class 1b antidysrhythmic agent.

Uses

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Indications

  • May be useful in dogs where lidocaine is ineffective.
  • Used in human medicine to control ventricular arrhythmias   Heart: dysrhythmia  following myocardial infarction.

Administration

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Pharmocokinetics

Precautions

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Interactions

with other drugs

Atropine and opioid analgesics
  • The absorption of mexiletine may be delayed.

  • Acetazolamide and alkaline urine
  • Mexiletine excretion may be reduced (due to antacids and adsorbents).

  • Phenytoin and rifampicin
  • The metabolism of mexiletine may be increased.

Adverse Reactions

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Further Reading

Publications

Other sources of information

  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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