Felis ISSN 2398-2950

Metronidazole

Contributor(s): Vetstream Ltd

Introduction

Name

  • Metronidazole.

Class of drug

  • Synthetic nitroimidazole.

Uses

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Indications

  • Anaerobic infections (eg Bacteroides spp Bacteroides fragilisClostridium spp Clostridium perfringens, etc) giardiasis Giardia spp and other protozoal infections.
  • Management of hepatic encephalopathy Hepatic encephalopathy.
  • Spiramycin is active against Gram-positive aerobes including Staphylococcus spp, Streptococcus spp, Bacillus spp, Actinomyces spp, Clostridium spp and Bacteroides spp.
  • Appetite stimulant in reptiles.
  • Adjunct to treatment of pyothorax.

Administration

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Precautions

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Interactions

with other drugs

Phenobarbital or phenytoin

  • May increase metabolism of metronidazole.

Cimetidine

  • May decrease metabolism of metronidazole and increase the likelihood of dose-related adverse effects occurring.

with diagnostic tests

  • The one-stage prothrombin (OSPT) time in patients on warfarin may be prolonged by metronidazole.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Scorza A V & Lappin M R (2004) Metronidazole for the treatment of feline giardiasis. J Feline Med Surg 6(3), 157-160 PubMed.
  • Caylor K B & Cassimatis M K (2001) Metronidazole neurotoxicosis in two cats. JAAHA 37, 258-262.

Other sources of information

  • Ramsey I (2017) BSAVA Small Animal Formulary. 9th edn.
  • Based on Small Animal Formulary. Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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