Felis ISSN 2398-2950

Metronidazole

Introduction

Name

  • Metronidazole.

Class of drug

  • Synthetic nitroimidazole.

Uses

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Indications

  • Anaerobic infections (egBacteroidesspp   Bacteroides fragilis  ,Clostridiumspp   Clostridium perfringens  , etc) giardiasis   Giardia spp  and other protozoal infections.
  • Management of hepatic encephalopathy   Hepatic encephalopathy  .
  • Spiramycin is active against Gram-positive aerobes includingStaphylococcusspp,Streptococcusspp,Bacillusspp,Actinomycesspp,Clostridiumspp andBacteroidesspp.
  • Appetite stimulant in reptiles.
  • Adjunct to treatment of pyothorax .

Administration

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Pharmocokinetics

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Precautions

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Interactions

with other drugs

Phenobarbital or phenytoin
  • May increase metabolism of metronidazole.
    Cimetidine
  • May decrease metabolism of metronidazole and increase the likelihood of dose-related adverse effects occurring.

with diagnostic tests

  • The one-stage prothrombin (OSPT) time in patients on warfarin may be prolonged by metronidazole.

Adverse Reactions

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Further Reading

Publications

Refereed papers

  • Scorza A V & Lappin M R (2004)Metronidazole for the treatment of feline giardiasis.J Feline Med Surg.6(3), 157-160.PubMed
  • Caylor K B & Cassimatis M K (2001)Metronidazole neurotoxicosis in two cats.JAAHA37, 258-262.

Other sources of information

  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.

ADDED