Felis ISSN 2398-2950

Methylprednisolone

Introduction

Name

  • Methylprednisolone.

Class of drug

  • Corticosteroid.

Uses

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Indications

  • Anti-inflammatory suitable for alternate day use.
  • Treatment for shock.

Administration

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Pharmocokinetics

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Precautions

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Interactions

with other drugs

Amphotericin B or potassium-depleting diuretics (Furosemide, thiazides)
  • Hypokalemia may develop.
    Insulin
  • Insulin requirements are likely to increase.
    Phenobarbital or phenytoin
  • The metabolism of corticosteroids may be enhanced.
  • Increased risk of gastrointestinal ulceration if used concurrently with NSAIDs.

with diagnostic tests

  • May increase urine glucose levels.
  • May decrease serum T3 and T4 values.
  • Will increase steroid induced alkaline phosphatase in dogs.
  • Some cross reaction with cortisol assay. May interfere with interpretation of other tests eg ACTH stimulation test.

Adverse Reactions

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Further Reading

Publications

Refereed papers

  • Ferasin L (2001)Iatrogenic hyperadrenocorticism in a cat following a short therapeutic course of methylprednisolone acetate.JFMS3, 87-93.

Other sources of information

  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.

ADDED