Felis ISSN 2398-2950

Methimazole

Synonym(s): Thiamazole

Contributor(s): Laura Johnston

Introduction

Class of drug

  • Thiourelyene anti-thyroid drug.

Description

Chemical name

  • Methimazole (thiamazole).

Molecular formula

  • C4H6N2S

Molecular weight

  • 114.17

Storage requirements

  • Do not store above 25°C.
  • Protect from moisture.

Uses

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Indications

  • Stabilization of hyperthyroidism   Hyperthyroidism   before surgical thyroidectomy   Thyroidectomy  .
  • Long-term control of feline hyperthyroidism.

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs

  • Phenobarbitone may decrease efficacy of methimazole.
  • Benzimidazole wormers decrease hepatic oxidation of these actives and may lead to increased circulating levels.
  • Thiamazole is immunomodulatory therefore this should be taken into account when considering vaccination programs.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references fromPubMed.
  • Fischetti A J, Drost W T, DiBartola S P, Chew D J, Schenck P A, Meadows C (2005)Effects of methimazole on thyroid gland uptake of 99mTC-pertechnetate in 19 hyperthyroid cats.Vet Radiol UltrasoundMay-Jun;46(3), 267-272PubMed.
  • Sartor L L, Trepanier L A, Kroll M M, Rodan I, Challoner L (2004)
    Efficacy and safety of transdermal methimazole in the treatment of cats with hyperthyroidism.J Vet Intern Med.Sep-Oct;18(5), 651-655PubMed.
  • Trepanier L A, Hoffman S B, Kroll M, Rodan I, Challoner L (2003) 
    Efficacy and safety of once versus twice daily administration of methimazole in cats with hyperthyroidism.JAVMAApr 1;222(7), 954-958PubMed.
  • Hoffmann G, Marks S L, Taboada J, Hosgood G L, Wolfsheimer K J (2003)Transdermal methimazole treatment in cats with hyperthyroidism.J Feline Med SurgApr;5(2), 77-82 PubMed.
  • Nieckarz J A, Daniel G B (2001)The effect of methimazole on thyroid uptake of pertechnetate and radioiodine in normal cats.Vet Radiol UltrasoundSep-Oct;42(5), 448-457PubMed.
  • Becker T J, Graves T K, Kruger J M, Braselton W E, Nachreiner R F (2000)Effects of methimazole on renal function in cats with hyperthyroidism.JAAHAMay-Jun;36(3), 215-223PubMed.
  • Peterson M E, Aucoin D P (1993)Comparison of the disposition of carbimazole and methimazole in clinically normal cats.Res Vet SciMay;54(3), 351-355PubMed.
  • Trepanier L A, Peterson M E, Aucoin D P (1991)Pharmacokinetics of methimazole in normal cats and cats with hyperthyroidism.Res Vet SciJan;50(1), 69-74PubMed.
  • Peterson M E, Kintzner P P & Hurvitz A I (1988)Methimazole treatment of 262 cats with hyperthyroidism.J Vet Int Med.2, 150-157PubMed.
  • Burden & Rosenthal (1983)Methimazole and insulin autoimmune syndrome.The Lancet(2),1311PubMed.
  • Hirata (1983)Methimazole and Insulin Autoimmune Syndrome with hypoglycaemiaThe Lancet(2), 1037-1038PubMed.

Other sources of information


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