Felis ISSN 2398-2950

Methadone

Contributor(s): Kyle Braund, John Dodam

Introduction

Name

  • Methadone.

Class of drug

  • Opioid analgesic (synthetic).
  • Schedule II Controlled Substance

Uses

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Indications

  • A synthetic opioid agonist used as a pre-anesthetic agent and for short-term pain control.
  • May be used in conjunction with acepromazine to produce neuroleptanalgesia for minor procedures, or pre-anesthetic medication.
  • It is often used with tranquilizer (eg diazepam) to produce deep sedation.
  • At equivalent doses to morphine the incidence of vomiting seems to be lower.

Administration

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Precautions

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Interactions

with other drugs

Central nervous system (CNS) depressants (anesthetics, antihistamines, barbiturates, phenothiazines, tranquilizers, etc)
  • May cause increased CNS or respiratory depression.

with diagnostic tests

Plasma amylase and lipase
  • Because narcotic analgesics can increase biliary tract pressure, plasma amylase or lipase levels may be increased up to 24 hours after narcotic administration.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Rohrer Bley C, Neiger-Aeschbacher G, Busato A & Schatzmann U (2004)Comparison of perioperative racemic methadone, levo-methadone and dextromoramide in cats using indicators of post-operative pain.Vet Anaesth Analg.31(3), 175-182.DOI
  • Dobromylskyj P (1996)Cardiovascular changes associated with anaesthesia induced by medetomidine combined with ketamine in cats.JSAP,37(4), 169-172.

Other sources of information

  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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