Felis ISSN 2398-2950

Meloxicam

Synonym(s): Metacam

Introduction

Name

  • Meloxicam.

Class of drug

  • Non-steroidal anti-inflammatory drug (NSAID).

Description

Chemical name

  • 4-hydroxy-2-methyl-N-(5-methyl-2-thiazolyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide.

Molecular formula

  • C14H13N3O4S2.

Physical properties

  • Pale yellow suspension.
  • Characteristic odor of honey.

Storage requirements

  • <25°C.

Uses

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Indications

  • Alleviate mild to moderate musculo-skeletal pain and inflammation.
    Analgesic action is enhanced if administered pre-emptively.

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs

Fluoroquinolones
  • Increase risk of convulsions (in man).

Anti-hypertensives, eg beta-blockers

  • Hypotensive effects may be antagonized.

Diuretics, aminoglycosides

  • May increase risk of nephrotoxicity.

with diagnostic tests

  • May cause false low values for T3 and T4.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references fromPubMed.
  • Jones C J, Streppa H K, Harmon B G & Budsberg S C (2002)In vivo effects of meloxicam and aspirin on blood, gastric mucosal, and synovial fluid prostanoid synthesis in dogs.Am J Vet Res63(11), 1527-1531.PubMed
  • Doig P A, Purbrick K A, Hare J E & McKeown D B (2000)Clinical efficacy and tolerance of meloxicam in dogs with chronic osteoarthritis.Can Vet J41, 296-300.PubMed
  • Rainsford K Det al(1999)Effects of the NSAIDs meloxicam and indomethacine on cartilage proteoglycan synthesis and joint responses to calcium pyrophosphate crystals in dogs.Vet Res Commun23(2), 101-113.PubMed

Other sources of information


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