Felis ISSN 2398-2950

Marbofloxacin

Contributor(s): Lauren Trepanier

Introduction

Name

  • Marbofloxacin.

Class of drug

  • Antibiotic.
  • Concentration-dependent bactericidal and antimicrobial.
  • Fluoroquinolone.

Uses

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Indications

Infections
  • Effective against mycoplasmas and many gram-positive and gram-negative organisms includingPasteurellaspp   Pasteurella multocida  ,Staphylococcusspp   Staphylococcus spp  ,Pseudomonas aeruginosa  Pseudomonas spp , Klebsiellaspp   Klebsiella pneumoniae  ,Escherichia coli  Escherichia coli , Proteusspp   Proteus spp   andSalmonellaspp   Salmonella spp  .
  • Aerobic.
  • Fluoroquinones are highly lipophilic and attain high concentrations within cells in many tissues.
  • Particularly effective in soft tissue, urogenital (including prostatitis) and skin infections.
    Ineffective against anaerobic infections, most Streptococcus and Enterococcus.

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs

Adsorbents and antacids
  • Containing cations (Mg, Al) bind to fluoroquinolones and prevent their absorption from the GIT, dramatically decreasing bioavailability.

Sucralfate and zinc salts

  • May inhibit the absorption of fluoroquinolones, separate doses of these drugs by at least 6 hours.

Theophylline

  • Fluoroquinolones increase plasma theophilline concentrations.

Probenecid

  • Blocks the tubular secretion of fluoroquinolones and may increase their blood level and half-life.

Adverse Reactions

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Further Reading

Publications

Other sources of information

  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA. ISBN: 0 9052 1452 8.

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