ISSN 2398-2950      

Lotilaner

ffelis

Synonym(s): Credelio®


Introduction

Name

  • Lotilaner.

Class of drug

  • Ectoparasiticide.
  • Isoxazoline.

Description

Chemical name

  • 5-[(5S)-4,5-dihydro-5-(3,4,5-trichlorophenyl)- 5-(trifluoromethyl)-3-isoxazolyl]-3-methyl-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]- 2-thiophenecarboxamide

Molecular formula

  • C20H14Cl3F6N3O3S

Molecular weight

  • 596.75

Physical properties

  • Chewable tablet (white to beige round tablet with brownish spots).

Storage requirements

  • Does not have any special storage conditions.
  • Shelf life: 2 years.

Uses

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Indications

Countries Fleas Ticks
UK/EU Treatment and prevention of flea infestations (Ctenocephalides felis)
Can be used as part of a treatment strategy for control of
flea allergy dermatitis (FAD) Flea bite hypersensitivity
Treatment of tick (Ixodes ricinus) infestations
USA Treatment and prevention of flea infestations (Ctenocephalides felis)                           -
  • Fleas and ticks must attach to the host and commence feeding in order to be exposed to lotilaner.

Administration

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Pharmacokinetics

Precautions

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Interactions

With other drugs

  • None known.
  • During clinical testing, no interactions were observed between lotilaner and veterinary products in routine use.

Adverse Reactions

This article is available in full to registered subscribers

Sign up now to obtain ten tokens to view any ten Vetlexicon articles, images, sounds or videos, or Login

Further Reading

Publications

Refereed Papers

  • Recent references from VetMedResource and PubMed.
  • Cavalleri D, Murphy M, Seewald W, Drake J, Nanchen S (2018) Laboratory evaluation of the efficacy and speed of kill of lotilaner (Credelio™) against Ixodes ricinus ticks on cats. Parasites & Vectors 11, 413 PubMed Full article.
  • Cavalleri D, Murphy M, Seewald W, Nanchen S (2018) Laboratory evaluation of the efficacy and speed of kill of lotilaner (Credelio™) against Ctenocephalides felis on cats. Parasites & Vectors 11, 408 PubMed Full article.
  • Cavalleri D, Murphy M, Seewald W, Nanchen S (2018) A randomized, controlled field study to assess the efficacy and safety of lotilaner (Credelio™) in controlling fleas in client-owned cats in Europe. Parasites & Vectors 11, 410 PubMed Full article.
  • Cavalleri D, Murphy M, Seewald W, Nanchen S (2018) A randomized, controlled field study to assess the efficacy and safety of lotilaner (Credelio™) in controlling ticks in client-owned cats in Europe. Parasites & Vectors 2018 11, 411 PubMed Full article.
  • Kuntz E A, Kammanadiminti S (2018) Safety of lotilaner flavoured chewable tablets (Credelio™) after oral administration in cats. Parasites & Vectors 11, 409 PubMed Full article.
  • Rufener L, Danelli V, Bertrand D, Sager H (2017) The novel isoxazoline ectoparasiticide lotilaner (Credelio™): a non-competitive antagonist specific to invertebrates γ-aminobutyric acid-gated chloride channels (GABACls). Parasites & Vectors 10, 530 PubMed Full article.
  • Toutain C E, Seewald W, Jung M (2018) Pharmacokinetics of lotilaner following a single oral or intravenous administration in cats. Parasites & Vectors 11, 412 PubMed Full article.
  • Wright I (2018) Lotilaner - a novel formulation for cats provides systemic tick and flea control. Parasites & Vectors 11, 407 PubMed Editorial.

Other sources of information

MEMBER BENEFIT

Can’t find what you’re looking for?

We have an ever growing content library on Vetlexicon so if you ever find we haven't covered something that you need please fill in the form below and let us know!