Felis ISSN 2398-2950

Lotilaner

Synonym(s): Credelio®

Contributor(s): Vetstream Ltd, Linda Horspool

Introduction

Name

  • Lotilaner.

Class of drug

  • Ectoparasiticide.
  • Isoxazoline.

Description

Chemical name

  • 5-[(5S)-4,5-dihydro-5-(3,4,5-trichlorophenyl)- 5-(trifluoromethyl)-3-isoxazolyl]-3-methyl-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]- 2-thiophenecarboxamide

Molecular formula

  • C20H14Cl3F6N3O3S

Molecular weight

  • 596.75

Physical properties

  • Chewable tablet (white to beige round tablet with brownish spots).

Storage requirements

  • Does not have any special storage conditions.
  • Shelf life: 2 years.

Uses

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Indications

  • For the treatment of flea (Ctenocephalides felis and C. canis Ctenocephalides canis) and tick (Ixodes ricinus Ixodes ricinus) infestations on cats for 1 month.
  • Can be used as part of a treatment strategy for control of flea allergy dermatitis (FAD) Flea bite hypersensitivity.
  • Fleas and ticks must attach to the host and commence feeding in order to be exposed to lotilaner.

Administration

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Pharmocokinetics

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Precautions

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Interactions

With other drugs

  • None known.
  • During clinical testing, no interactions were observed between lotilaner and veterinary products in routine use.

Adverse Reactions

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Further Reading

Publications

Refereed Papers

  • Recent references from VetMedResource and PubMed.
  • Cavalleri D, Murphy M, Seewald W, Drake J, Nanchen S (2018) Laboratory evaluation of the efficacy and speed of kill of lotilaner (Credelio™) against Ixodes ricinus ticks on cats. Parasites & Vectors 11, 413 PubMed Full article.
  • Cavalleri D, Murphy M, Seewald W, Nanchen S (2018) Laboratory evaluation of the efficacy and speed of kill of lotilaner (Credelio™) against Ctenocephalides felis on cats. Parasites & Vectors 11, 408 PubMed Full article.
  • Cavalleri D, Murphy M, Seewald W, Nanchen S (2018) A randomized, controlled field study to assess the efficacy and safety of lotilaner (Credelio™) in controlling fleas in client-owned cats in Europe. Parasites & Vectors 11, 410 PubMed Full article.
  • Cavalleri D, Murphy M, Seewald W, Nanchen S (2018) A randomized, controlled field study to assess the efficacy and safety of lotilaner (Credelio™) in controlling ticks in client-owned cats in Europe. Parasites & Vectors 2018 11, 411 PubMed Full article.
  • Kuntz E A, Kammanadiminti S (2018) Safety of lotilaner flavoured chewable tablets (Credelio™) after oral administration in cats. Parasites & Vectors 11, 409 PubMed Full article.
  • Rufener L, Danelli V, Bertrand D, Sager H (2017) The novel isoxazoline ectoparasiticide lotilaner (Credelio™): a non-competitive antagonist specific to invertebrates γ-aminobutyric acid-gated chloride channels (GABACls). Parasites & Vectors 10, 530 PubMed Full article.
  • Toutain C E, Seewald W, Jung M (2018) Pharmacokinetics of lotilaner following a single oral or intravenous administration in cats. Parasites & Vectors 11, 412 PubMed Full article.
  • Wright I (2018) Lotilaner - a novel formulation for cats provides systemic tick and flea control. Parasites & Vectors 11, 407 PubMed Editorial.

Other sources of information


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