Felis ISSN 2398-2950

Lomustine

Synonym(s): CeeNU, CCNU

Contributor(s): William Brewer Jr

Introduction

Name

  • Lomustine.

Class of drug

  • Alkylating agent in the nitrosurea family.

Description

Chemical name

  • 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosurea.

Molecular formula

  • C9H16C1N3O2

Molecular weight

  • 233.71

Physical properties

  • Yellow powder.

Storage requirements

  • Stable if stored in well closed containers at room temperature until expiration date indicated on package. Avoid excessive heat over 40°C.

Uses

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Indications

  • Granulomatous meningioencephalitis (GME), other inflammatory CNS diseases.
  • Indicated as a single agent or as part of combination therapy in the treatment of high grade or metastatic mast cell tumors   Mastocytoma  , epitheliotropic or refractory lymphoma   Lymphoma   and multiple myeloma   Multiple myeloma  .

Administration

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Pharmocokinetics

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed.
  • Saba C F, Thamm DH & Vail D M (2009)Combination chemotherapy with continuous L-asparaginase, lomustine, and prednisone for relapsed or refractory canine lymphoma.JVIM23(5), 1058-1063PubMed.
  • Rassnick K Met al(2008)Lomustine for treatment of mast cell tumors in cats: 38 cases (1999-2005).JAVMA232(8), 1200-1205PubMed.
  • Kristal Oet al(2004)Hepatotoxicity associated with CCNU (lomustine) chemotherapy in dogs.JVIM18(1), 75-80PubMed.
  • Fan T Met al(2002)Hematological toxicity and therapeutic efficacy of lomustine in 20 tumor-bearing cats: critical assessment of a practical dosing regimen.JAAHA38(4), 357-363.
  • Rassnick K Met al(2001)Phase 1 evaluation of CCNU (lomustine) in tumor-bearing cats.JVIM15(3), 196-199PubMed.

Other sources of information

  • Tennant B (2005)BSAVA Small Animal Formulary.5th edn. Quedgeley, Gloucester, UK.

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