Felis ISSN 2398-2950

Lincomycin

Contributor(s): Lauren Trepanier

Introduction

Name

  • Lincomycin.

Class of drug

  • Lincosamide antibiotic.

Description

Physical properties

  • Compatible in DSW, 0.9% saline, Ringers.
  • Compatible with heparin.

Uses

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Indications

  • A lincosamide antibiotic that is active against gram-positive cocci (including penicillin-resistant staphylococci) and many anaerobes (includingBacteroidesspp   Bacteroides fragilis   and  Clostridium tetani ).
  • Either bacteriostatic or bactericidal depending on the organism and drug concentration.
  • Particularly indicated for staphylococcal bone and joint infections.
  • Clindamycin   Clindamycin  is more active than lincomycin, particularly against anaerobes and is better absorbed from the gut.

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs

Neuromuscular blocking agents
  • May be enhanced if given with lincomycin.

Kaolin

  • The absorption of lincomycin may be reduced.

Erythromycin

  • May prevent the binding of lincomycin to its site of action.

Further Reading

Publications

Other sources of information

  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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