ISSN 2398-2950      

Lidocaine

ffelis
Contributor(s):

Kyle Braund

Jo Murrell

Synonym(s): Lignocaine


Introduction

Name

  • Lidocaine.

Class of drug

  • Amide-linked local anesthetic.
  • Class 1B antidysrhythmic.

Uses

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Indications

  • Drug of choice for treating acute ventricular dysrhythmias Heart: dysrhythmia.
  • Used predominantly as a local anesthetic.
  • Not advisable for the provision of intra-operative and post-operative analgesia by continuous rate infusion intravenously due to the risk of cardiovacular depression.

Administration

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Precautions

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Interactions

with other drugs

Cimetidine

  • May increase serum lidocaine levels or its effects if administered concurrently.

Propranolol

  • May increase serum lidocaine levels or its effects if administered concurrently.

Procainamide

  • May cause additive CNS effects.

Other anti-dysrhythmics

  • May cause increased myocardial depression.

Acetazolamide, loop diuretics and thiazides

  • The effect of lidocaine may be antagonized by hypokalemia with the above drugs.

Suxamethonium

  • Large doses of lidocaine may prolong suxamethonium-induced apnea.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Vieitez V, Gómez de Segura I Á, Martin-Cuervo M, Gracia L A, Ezquerra L J (2017) Successful use of lipid emulsion to resuscitate a foal after intravenous lidocaine induced cardiovascular collapse. Equine Vet J 49(6), 767-769 PubMed.
  • Cassutto B H & Gfeller R W (2003) Use of intravenous lidocaine to prevent reperfusion injury and subsequent multiple organ dysfunction syndromeJ Vet Emerg Crit Care 13(3), 137.
  • Jones R S (2001) Epidural analgesia in the dog and cat. Vet J  161(2), 123-131.
  • Lemke K A & Dawson S D (2000) Local and regional anesthesia. Vet Clin North Am Small Anim Pract 30(4), 839-857.

Other sources of information

  • Based on Small Animal Formulary. Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.
  • Plumb D C (1999) Veterinary Drug Handbook. 3rd edn. Iowa State University Press, Ames. pp 379-381.
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