Felis ISSN 2398-2950

Ketoconazole

Contributor(s): Stephen Barr

Introduction

Name

  • Ketoconazole.

Class of drug

  • Imidazole antifungal agent.

Uses

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Indications

  • Used to treat aspergillosis   Aspergillosis  , candidiasis   Candida albicans  , blastomycoses, coccidiomycoses, cryptococcosis   Cryptococcosis  , sporotrichosis and dermatophytosis.
  • It is used in the treatment of hyperadrenocorticism   Hyperadrenocorticism  in dogs that do not tolerate mitotane   Mitotane  and in cats.
    Its efficacy in management of hyperadrenocorticism is variable.

Administration

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Precautions

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Interactions

with other drugs

Drugs increasing pH of gastric contents (eg antacids, antimuscarinics and H2 blockers)
  • The absorption of ketoconazole may be impaired; stagger dosing of these drugs around ketoconazole dose.

Methylpredniselone

Phenytoin

  • Plasma ketoconazole levels are reduced by phenytoin   Phenytoin  .

Antihistamines, oral hypoglycemics, antiepileptics, cisapride and ciclosporin

  • Antifungal imidazoles and triazoles inhibit metabolism of these drugs but interactions have not been studied in veterinary field.

Adverse Reactions

This article is available in full to registered subscribers

Sign up now to purchase a 30 day trial, or Login

Further Reading

Publications

Other sources of information

  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.

ADDED