Felis ISSN 2398-2950

Isoflurane

Contributor(s): Kyle Braund

Introduction

Name

  • Isoflurane.

Class of drug

  • Inhalational anesthetic.

Description

Physical properties

  • Volatile halogenated ether liquid.

Storage requirements

  • Store at room temperature.

Uses

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Indications

  • An inhalational anesthetic   General anesthesia: overview  .
  • Induction and maintenece of anesthesia for all types of surgery and in all species, irrespective of age.
    Rapid recovery following painful eg orthopedic procedures, necessitates appropriate and rapid attention to analgesia   Analgesia: overview  .
  • Assertions that isoflurane is safer in certain high risk cases should be discounted.

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs

  • Duration of non-depolarizing neuromuscular blocking agents is longer in isoflurane, compared with halothane-anesthetized animals.
  • Opioid agonists, benzodiazepines and nitrous oxide   Nitrous oxide  reduce the concentration of isoflurane required to acheive surgical anesthesia.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Yackey M, Ilkiw J E, Pascoe P J & Tripp L D (2004)Effect of transdermally administered fentanyl on the minimum alveolar concentration of isoflurane in cats.Vet Anaesth Analg.31(3), 183-189.DOI
  • Lerche P, Muir WW & Grubb TL (2002)Mask induction of anaesthesia with isoflurane or sevoflurane in premedicated cats.J Small Anim Pract.43(1), 12-15.
  • Clarke KW (1999)Desflurane and sevoflurane. New volatile anesthetic agents.Vet Clin North Am Small Anim Pract.29(3), 793-810.
  • Hikasa Y, Yamashita M, Takase K, Ogasawara S (1998)Prolonged sevoflurane, isoflurane and halothane anaesthesia in oxygen using rebreathing or non-rebreathing system in cats.Zentralbl Veterinarmed A.45(9), 559-575.

Other sources of information

  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA. ISBN: 0 9052 1452 8.
  • Plumb DC (1999)Veterinary Drug Handbook. 3rd edn. Iowa State University Press, Ames. pp 348-349.

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