Felis ISSN 2398-2950

Insulin detemir

Contributor(s): Dr Linda Fleeman

Introduction

Name

  • Insulin detemir.

Class of drug

  • Insulin analogue.

Description

Molecular formula

  • C267H402O76N64S6

Molecular weight

  • 5913

Physical properties

  • Clear, sterile, aqueous solution containing 100 unit/mL.

Storage requirements

  • Should be stored in refrigerator before use, but may be kept for 28 days at room temperature away from direct light and heat (<30°C) when contained within an insulin dosing pen that is in use.
  • Once vials are in use, the manufacturer recommends discarding unused insulin after 28 days.  However, problems have not been reported with continued use beyond 28 days.

Uses

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Indications

  • To treat diabetes mellitus in cats.
  • To treat diabetic dogs that do not respond to lente or NPH insulin preparations   Insulin    Insulin glargine  .

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs

  • There are no known interactions of detemir with other drugs, but in general the following drugs may increase or decrease the effect of insulin.
  • Drugs which potentiate the effect of insulin include:
  • Drugs which reduce the glucose lowering effects of insulin include:
    • Corticosteroids.
    • Dobutamine    Dobutamine  .
    • Adrenalin.
    • Thiazide diuretics.
    • Thyroid hormones.

with diagnostic tests

  • Not known.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from VetMed Resource and PubMed.
  • Sparkes A, Cannon M, Church D, Fleeman Let al(2016) ISFM consensus guidelines on the practical management of diabetes mellitus in cats.J Feline Med Surg17, 235-250PubMed.
  • Thompson A L, Lathan P, Fleeman L M (2015) Update on insulin treatment for dogs and cats: insulin dosing pens and more.Veterinary Medicine: Research and Reports6, 129-142 https://www.dovepress.com/update-on-insulin-treatment-for-dogs-and-cats-insulin-dosing-pens-and--peer-reviewed-article-VMRR.
  • Gilor C, Graves T K (2010)Synthetic insulin analogs and their use in dogs and cats.Vet Clin North Am Small Anim Pract40, 297-307PubMed.
  • Gilor C, Ridge T K, Attermeier K J, Graves T K (2010) Pharmacodynamics of insulin detemir and insulin glargine assessed by an isoglycemic clamp method in healthy cats.J Vet Intern Med24, 870-874PubMed.

Other sources of information

  • Fracassi F, Hafner M, Corradini S, Boretti F, Sieber-Ruckstuhl N, Reusch C (2012)Use of insulin detemir in dogs with diabetes mellitus.Paper presented at theEuropean College of Veterinary Internal Medicine-Companion Animal Congress, Maastricht, The Netherlands.
  • Ford S L, Rand J S, Ghormley T M,  Lynch H M (2010)Evaluation of Detemir Insulin in Diabetic Dogs Managed with Home Blood Glucose Monitoring.Paper presented at:American College of Veterinary Internal Medicine Forum 2010; Anaheim, California.

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