ISSN 2398-2950      

Indoxacarb

ffelis

Synonym(s): Activyl®, Activyl® Tick Plus


Introduction

Name

  • IUPAC.

Class of drug

  • Pro-insecticide belonging to oxadiazine chemical family.

Description

Chemical name

  • Methyl 7-chloro-2,5-dihydro-2-[[(methoxycarbonyl)[4-(trifluoromethoxy)phenyl]amino]carbonyl]indeno[1,2-e][1,3,4]oxadiazine-4a(3H)-carboxylate.

Molecular formula

  • C22H17ClF3N3O7

Molecular weight

  • 527.84

Physical properties

  • Indoxacarb:
    • Water solubility = 15 ppm.
    • Octanol-water Partition Coefficient (log P, pH7) = 4.65.
    • Photolysis  half-life (at 25°C, pH5) = 3.16 days.
  • Finished product:
    • Spot-on solution.
    • A clear, colorless to yellow solution.

Storage requirements

  • Product as packaged for sale:
    • Store in the original package in order to protect from moisture.
    • No special storage requirements (room temperature 9 to 25°C).

Uses

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Indications

  • Ectoparasiticide. Insecticide. Adulticide. Larvicide. Ovicide.
  • Treatment and prevention of flea infestation (Ctenocephalides felis  Ctenocephalides felis  ).
  • Can be used as part of a treatment strategy for flea allergy dermatitis (FAD)   Flea bite hypersensitivity  .
  • Developing stages of fleas in the pet's immediate surroundings are killed following contact with treated pets.

Administration

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Pharmacokinetics

Precautions

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Interactions

with other drugs

  • None known.
  • Indoxacarb has been co-administered with 4% deltamethrin-impregnated collars without evidence of associated adverse reactions.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from VetMedResource and PubMed.
  • Dryden M W, Payne P A, Smith V, Heaney K, Sun F (2013) Efficacy of indoxacarb applied to cats against the adult cat flea, Ctenocephalides felis, flea eggs and adult flea emergence. Parasit Vectors 6, 126 PubMed
  • Lapied B, Grolleau F, Sattelle D B (2001) Indoxacarb, an oxadiazine insecticide, blocks insect neuronal sodium channels. Br J Pharmacol 132, 587-595 PubMed.
  • McCann S F, Annis G D, Shapiro R, Piotrowski D W, Lahm G P, Long J K, Lee K C, Hughes M M, Myers B J, Griswold S M, Reeves B M, March R W, Sharpe P L, Lowder P, Barnette W E, Wing K D (2001) The discovery of indoxacarb: oxadiazines as a new class of pyrazoline-type insecticides. Pest Manag Sci 57, 153-164 PubMed.

Other sources of information

Organisation(s)

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