Felis ISSN 2398-2950

Hydrochlorothiazide

Introduction

Name

  • Hydrochlorothiazide.

Class of drug

  • Thiazide diuretic.

Uses

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Indications

  • Ascites.
  • Pleural effusion   Pleural effusion  .
  • Edema.
  • Hypertension   Hypertension  .
  • When using hydrochlorthiazide to treat hypertension, if potassium loss is/may be a clinical problem, it should be used in combination with a potassium sparing diuretic (eg amiloride).
  • To inhibit lactation in pseudopregnancy.

Administration

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Pharmocokinetics

Precautions

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Interactions

with other drugs

Corticosteroids
  • Increased possibility of hypokalemia developing.

Digoxin

  • Thiazide-induced hypokalemia may increase the risk of digoxin toxicity   Digoxin  . Thus, potassium therapy may be necessary during prolonged administration.

Sulfonamides

  • May potentiate thiazide activity.

Quinidine

  • Half-life may be prolonged by thiazides (alkalinizes urine)   Quinidine  .

Diazoxide

  • Increased chance of hyperglycemia, hyperuricemia and hypotension.

Vitamin D or calcium salts

  • May exacerbate hypercalcemia.

Adverse Reactions

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Further Reading

Publications

Other sources of information

  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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