Felis ISSN 2398-2950

Glycopyrronium

Synonym(s): Glycopyrrolate

Contributor(s): Kyle Braund

Introduction

Name

  • Glycopyrronium bromide.

Class of drug

  • Antimuscarinic agent.

Uses

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Indications

  • Used preoperatively to decrease oral and bronchial secretions and block vagal inhibitory reflexes. (similar actions as atropine)
  • Its routine use for preanesthetic medication in dogs is controversial.
  • In conjunction with long-acting anticholinesterase drugs eg neostigmine, pyridostigmine during antagonism of neuromuscular block.

Administration

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Precautions

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Interactions

with other drugs

Atropine, chlorpromazine, 5% dextrose, diphenhydramine, droperidol/fentanyl, lidocaine, morphine, neostigmine, pethidine, promazine, pyridostigmine, Ringers solution and 0.9% sodium chloride
  • Glycopyrronium is physically compatible.

Alkaline drugs (eg barbiturates)

  • When mixed a precipitate may form.

Antihistamines, benzodiazepines, prolonged corticosteroid use (may increase intraocular pressure), pethidine, phenothiazines, procainamide and quinidine

  • The adverse effects of antimuscarinics may be increased.

Nitrofurantoin, sympathomimetics and thiazide diuretics

  • Antimuscarinics may enhance the action.

Metoclopramide

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Skarda RT, Muir WW, Bednarski RM, Hubbell JA & Mason DE (1995)Sedation and anesthesia in dogs and cats with cardiovascular disease. II. Anesthesia planning with respect to pathophysiology, heart arrhythmia.Schweiz Arch Tierheilkd.137(12), 543-551. (In German)

Other sources of information

  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.
  • Plumb DC (1999)Veterinary Drug Handbook.3rd edn. Iowa State University Press, Ames. pp 309-311.

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