Felis ISSN 2398-2950

Glipizide

Synonym(s): Glibenase, Minodiab

Introduction

Name

  • Glipizide.

Class of drug

  • Sulfonylurea.

Description

Physical properties

  • White powder.

Storage requirements

  • Store in light-tight containers.

Uses

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Indications

  • Management of type-II or non-insulin-dependent diabetes mellitus (NIDDM)   Diabetes mellitus  where there is some residual insulin production.
  • In these cases it may be effective alone or administered with insulin to reduce insulin requirements.
  • Glipizide is ineffective when there is an absolute insulin deficiency (IDDM) or when insulin resistance is present.

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs

  • The effects of glipizide may be enhanced by ACE inhibitors, NSAIDs, chloramphenicol, potentiated sulfonamides and fluoroquinolones.
  • Glipizide may prolong the action of barbiturates.
  • Probencid, cimetidine or monoaminoxidase inhibitors may increase the hypoglycemic effects of glipizide.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Hoenig M, Hall G, Ferguson Det al(2000)A feline model of experimentally induced islet amyloidosis.Am J Pathol157, 2143-2150.

Other sources of information

  • Based onSmall Animal Formulary.Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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