Felis ISSN 2398-2950

Fentanyl (transdermal patch)

Contributor(s): Sheilah Robertson, John Dodam

Introduction

Name

  • Transdermal fentanyl.
  • Duragesic fentanyl transdermal system.

Class of drug

  • Opioid analgesic (narcotic), schedule II /classII drug (requires DEA controlled drug license, ordering forms and all required documentation).
  • After use, the patch must be disposed of according to DEA regulations for a schedule II drug.

Description

Chemical name

  • N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide.

Molecular formula

  • C22H28N2O

Molecular weight

  • 336.47

Physical properties

  • Product is transdermal system designed to deliver 12, 25, 50, 75 or 100 micrograms fentanyl/h through human skin.

Storage requirements

Uses

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Indications

  • Not approved for veterinary use.
  • This product is used in veterinary medicine for alleviation of acute pain following trauma or surgery. It can be used for chronic pain management, for example in cancer patients.

Administration

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Pharmocokinetics

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Precautions

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Interactions

with other drugs

  • After effective fentanyl plasma levels have been achieved, the use of other pure opioid agonists may result in an additive effect. In contrast, administration of agonist-antagonist drugs (ie butorphanol   Butorphanol tartrate  ) has the potential to antagonize the actions of fentanyl.

Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed.
  • Yackey M, Ilkiw J E, Pascoe P J & Tripp L D (2004)Effect of transdermally administered fentanyl on the minimum alveolar concentration of isoflurane in cats.Vet Anaesth Analg.31(3), 183-189.DOI
  • Gellasch KL, Kruse-Elliott KT, Osmond CSet al(2002)Comparison of transdermal administration of fentanyl versus intramuscular administration of butorphanol for analgesia after onychectomy in cats.J Am Vet Med Assoc.220, 1020-1024.
  • Glerum LE, Egger CM, Allen SW & Haag M (2001)Analgesic effect of the transdermal fentanyl patch during and after feline ovariohysterectomy.Vet Surg.30(4), 351-358.
  • Franks JN, Boothe HW & Taylor Let al(2000)Evaluation of transdermal fentanyl patches for analgesia in cats undergoing onychectomy.J Am Vet Med Assoc.217(7), 1013-1020.

Other sources of information


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